Nonsmall Cell Lung Adenocarcinoma Metastatic to the Vitreous Without Fundus Lesions

Abstract

Abstract. A 76-year-old man presented with vitritis in the absence of visible fundus lesions. Vitreal cytologie analysis revealed adenocarcinoma; immunostaining was consistent with a pulmonary origin. This case highlights the need to exclude metastasis to the vitreous in a patient with an oncologie history, even in the absence of visible posterior segment lesions. It also illustrates the utility of immunostaining to better determine the tissue of origin when a metastatic lesion is encountered. [Ophthalmic Surg Lasers 2000;31:155-156]

Isolated Vitreous Metastasis in a Patient With an Anaplastic Lymphoma Kinase–positive Lung Cancer Treated With Lorlatinib

“…They have been previously reported in association with skin melanoma, 5 breast cancer, 6 and lung cancer. [1][2][3] It has been postulated that vitreous cells could spread from the central nervous system to the vitreous cavity through the optic nerve, 5 come from a choroidal metastasis through the retina or leak from the vessels into the vitreous. In our case, there was no evidence of retinal or choroidal involvement, so the optic nerve spreading could be the most likely hypothesis even if it is difficult to exclude a hematologic spread just on the basis of the absence of leakage from the retinal vessels on fluorescein angiography.…”

“…They have been previously reported in association with skin melanoma, 5 breast cancer, 6 and lung cancer. 1–3…”

“…Only five cases of lung cancer metastasis to the vitreous confirmed by vitreous biopsy have been previously reported. [1][2][3] We report a case of a patient with metastatic anaplastic lymphoma kinase (ALK)-positive lung cancer on targeted therapy who presented with isolated vitreous metastasis confirmed by vitreous biopsy.…”