Nonsense shielding: protecting
            <scp>RNA</scp>
            from decay leads to cancer

Wilkinson, Miles; Cook-Andersen, Heidi

doi:10.15252/embj.2018101417

Cited by 1 publication

(1 citation statement)

References 10 publications

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“…Therefore, overall NMD efficiency has been suggested to be a compromise of balancing both efficiency with specificity and quality control with regulation [ 8 ]. Against the background of cell type and physiological situations, NMD thus specifically maintains a regulatory flexibility weighing the abundance of targets versus nontargets, the abundance of NMD factors and the abundance of feedback inducing proteins and mRNA features [ 8 , 228 , 229 ].…”

Section: To Nmd or Not To Nmd?mentioning

confidence: 99%

UPF1-Mediated RNA Decay—Danse Macabre in a Cloud

Lavysh

Neu‐Yilik

2020

Biomolecules

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Nonsense-mediated RNA decay (NMD) is the prototype example of a whole family of RNA decay pathways that unfold around a common central effector protein called UPF1. While NMD in yeast appears to be a linear pathway, NMD in higher eukaryotes is a multifaceted phenomenon with high variability with respect to substrate RNAs, degradation efficiency, effector proteins and decay-triggering RNA features. Despite increasing knowledge of the mechanistic details, it seems ever more difficult to define NMD and to clearly distinguish it from a growing list of other UPF1-mediated RNA decay pathways (UMDs). With a focus on mammalian NMD, we here critically examine the prevailing NMD models and the gaps and inconsistencies in these models. By exploring the minimal requirements for NMD and other UMDs, we try to elucidate whether they are separate and definable pathways, or rather variations of the same phenomenon. Finally, we suggest that the operating principle of the UPF1-mediated decay family could be considered similar to that of a computing cloud providing a flexible infrastructure with rapid elasticity and dynamic access according to specific user needs.

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