Nonself Mutations in the Spike Protein Suggest an Increase in the Antigenicity and a Decrease in the Virulence of the Omicron Variant of SARS-CoV-2

Otaki, Joji M.; Nakasone, Wataru; Nakamura, Morikazu

doi:10.3390/covid2030029

Cited by 5 publications

(6 citation statements)

References 77 publications

(163 reference statements)

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“…While this is a positive aspect, a reasonably high rate of transmission could quickly exhaust existing healthcare ability, resulting in more deaths than predicted. Such healthcare stress may also lead to an increase in mortalities that are not linked to COVID‐19 62 . Omicron multiplies 70 times faster in tissues that line airway passages than the earlier Delta variant, potentially facilitating person‐to‐person spread, according to the researchers.…”

Section: Disease Severitymentioning

confidence: 99%

Emerging evidence on Omicron (B.1.1.529) SARS‐CoV‐2 variant

Sharma

Rai

Gautam

et al. 2022

Journal of Medical Virology

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COVID's Omicron variant has sparked a slew of concerns across the globe. This review aims to provide a brief overview of what we know about the Omicron variant right now. The new variant has been discovered in 149 countries across all six World Health Organization (WHO) regions since its discovery in South Africa on November 24, 2021 and became the dominant variant in the country in less than 3 weeks. The WHO has warned that the B.1.1.529 variant is spreading at an unprecedented rate, and has urged countries to prepare for the worst. Over the course of this time, researchers from Africa and around the world have uncovered a wealth of information about the virus's epidemiology and biological properties. Case numbers are increasing exponentially in hard‐hit areas such as South Africa, United Kingdom, and USA (overtaking the delta variant), implying that the variant is highly transmissible. Initial research has provided some insights into the efficacy of vaccines against the Omicron variant and whether it produces major illness, however, much remains unknown, and additional work is needed to investigate what the initial reports represent in real‐world situations.

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Section: Disease Severitymentioning

confidence: 99%

Emerging evidence on Omicron (B.1.1.529) SARS‐CoV‐2 variant

Sharma

Rai

Gautam

et al. 2022

Journal of Medical Virology

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“…It was recently found that despite its greater infectivity and transmissibility, the Omicron variant has evolved to have higher antigenicity and decreased pathogenicity in humans. This was determined by the low number of nonself stretches of short constituent sequences (NSC) in both the Omicron and Delta proteomes; however, the number of NSCs was much higher in the RBD of the Omicron spike sequence than in the Delta spike sequence [ 26 ]. These NSCs assist in identifying and escaping the immune response.…”

Section: Resultsmentioning

confidence: 99%

Omicron variant receptor-binding domain phylogenetics and molecular dynamics

Kandeel

El-Deeb

2022

Computers in Biology and Medicine

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“…This book discussed different mathematical analyses of infectious diseases, especially regarding COVID-19. Another significant work was completed by Otaki et al [ 36 ]. They checked the distributions of SARS-CoV-2 non-self-mutation in the Omicron and Delta variants.…”

Section: Related Workmentioning

confidence: 99%

An Enhanced SEIR Model for Prediction of COVID-19 with Vaccination Effect

Poonia

Saudagar

AlTameem

et al. 2022

Life

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Currently, the spread of COVID-19 is running at a constant pace. The current situation is not so alarming, but every pandemic has a history of three waves. Two waves have been seen, and now expecting the third wave. Compartmental models are one of the methods that predict the severity of a pandemic. An enhanced SEIR model is expected to predict the new cases of COVID-19. The proposed model has an additional compartment of vaccination. This proposed model is the SEIRV model that predicts the severity of COVID-19 when the population is vaccinated. The proposed model is simulated with three conditions. The first condition is when social distancing is not incorporated, while the second condition is when social distancing is included. The third one condition is when social distancing is combined when the population is vaccinated. The result shows an epidemic growth rate of about 0.06 per day, and the number of infected people doubles every 10.7 days. Still, with imparting social distancing, the proposed model obtained the value of R0 is 1.3. Vaccination of infants and kids will be considered as future work.

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Nonself Mutations in the Spike Protein Suggest an Increase in the Antigenicity and a Decrease in the Virulence of the Omicron Variant of SARS-CoV-2

Cited by 5 publications

References 77 publications

Emerging evidence on Omicron (B.1.1.529) SARS‐CoV‐2 variant

Emerging evidence on Omicron (B.1.1.529) SARS‐CoV‐2 variant

Omicron variant receptor-binding domain phylogenetics and molecular dynamics

An Enhanced SEIR Model for Prediction of COVID-19 with Vaccination Effect

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