Abstract:Phosphorylation is one of the most common posttranslational protein modifications. It has multiple roles in cell signaling during development as well as for maintenance of diverse functions of an organism. Protein kinases and phosphatases control phosphorylation and play critical roles in cellular processes from cell birth to cell death. Discovery of hearing-loss-associated gene variants in humans and the study of animal models have identified a crucial role of a plethora of protein phosphatases and kinases in… Show more
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