Nonproliferative and Proliferative Lesions of the Ratand Mouse Special Sense Organs(Ocular [eye and glands], Olfactory and Otic)

Historical Data: Histopathology Lesions Observed in the Eyes of Control Rabbits in Topical Ocular Administration and Contact Lens Studies

“…Some of these findings were termed “dysplasia” in the study pathology reports but further described by the study pathologist as characterized by fold- or rosette-like structures. Given this, and since retinal dysplasias have been included in the diagnoses of retinal rosettes in the rodent INHAND nomenclature (Ramos et al 2018), they are tabulated into the “fold/rosette” category in the present work. However, some of these warrant additional descriptors as they lack prominent rosette formations or inward projecting folds and may therefore be more accurately described as dysplasia (Figures 30 and 31).…”

“…However, some of these warrant additional descriptors as they lack prominent rosette formations or inward projecting folds and may therefore be more accurately described as dysplasia (Figures 30 and 31). In addition, folds, if sectioned on a tangential plane, can look like rosettes (Ramos et al 2018). Therefore, these findings were categorized together under fold/rosette.…”

“…The majority of cases reviewed in this retrospective evaluation were disorganized, often with small cyst-like central spaces, occasional partial folding of the retina, and frequently gliosis of the NFL. Review of the study pathology reports revealed that most cases of folds and rosettes were grouped together under a single category as “fold” or “fold/rosette.” We believe that segregation of these diagnoses at times may be difficult, although they have differential features as described in the INHAND rodent ocular terminology (Ramos et al 2018). Specifically, folds may appear as rosettes if sectioned in a tangential plane (Ramos et al 2018), which could be easily imagined for a structure such as that presented in Figure 27.…”

“…Review of the study pathology reports revealed that most cases of folds and rosettes were grouped together under a single category as “fold” or “fold/rosette.” We believe that segregation of these diagnoses at times may be difficult, although they have differential features as described in the INHAND rodent ocular terminology (Ramos et al 2018). Specifically, folds may appear as rosettes if sectioned in a tangential plane (Ramos et al 2018), which could be easily imagined for a structure such as that presented in Figure 27. To demonstrate a spectrum of these findings, we have included representative images of findings that may be classified as folds (Figure 27), rosettes (Figures 28 and 29), and those findings which may be best characterized as general dysplasias (Figures 30 and 31) but were combined into the diagnosis of folds/rosettes.…”

“…In the interest of harmonized nomenclature, wherever possible, terminology to describe findings was translated to that proposed in the then draft manuscript from IN ternational HA rmonization of N omenclature and D iagnostic Criteria (INHAND) for the rodent eye (Ramos et al 2018). However, a few of the ocular findings in these studies are not described in the rodent INHAND list.…”