Nonpolymeric nanoassemblies for ocular administration of acyclovir: Pharmacokinetic evaluation in rabbits

Stella, Barbara; Berlier, Gloria; Rocco, Flavio; Burgalassi, Susi; Nicosia, N.; Tampucci, Silvia; Chetoni, Patrizia; Cattel, Luigi

doi:10.1016/j.ejpb.2011.10.001

Cited by 24 publications

(17 citation statements)

References 41 publications

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“…The apparent first order elimination rate constants (K e ) of CyA from the tear fluid and the corresponding half-lives (t 1 2 = 0.963/K e ) were calculated from linear phase of [log tear fluid concentration] vs. time plots [41]. The Areas Under Curve values (AUC) were calculated from 1 min to 30 min after instillation from appropriate graph applying the linear trapezoidal method.…”

Section: In Vivo Evaluation Of Precorneal Residence Time Of Cyamentioning

confidence: 99%

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

et al. 2020

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The physiological protective mechanisms of the eye reduce the bioavailability of topically administered drugs above all for those with high molecular weight and /or lipophilic characteristics, such as Cyclosporine A (CyA). The combined strategy based on the association of nanomicelles and mucoadhesive polymer seems promising since a limited number of commercial products containing CyA have been recently approved. The scope of this investigation was the design of Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano), based on a binary system of two surfactants in combination with hyaluronic acid, and their biopharmaceutical evaluation. The optimisation of the ASMP-Nano in term of the amount of surfactants, CyA-loading and size determined the selection of the clear and stable Nano1HAB-CyA formulation containing 0.105% w/w CyA loaded-nanomicelles with a size of 14.41 nm. The nanostructured system had a protective effect towards epithelial corneal cells with a cell viability of more than 80%. It interacted with cellular barriers favouring the uptake and the accumulation of CyA into the cells as evidenced by fluorescent probe distribution, by hindering CyA permeation through reconstituted corneal epithelial tissue. In pharmacokinetics study on rabbits, the nanomicellar carrier prolonged the CyA retention time in the precorneal area mainly in presence of hyaluronic acid (HA), a mucoadhesive polymer.

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Section: In Vivo Evaluation Of Precorneal Residence Time Of Cyamentioning

confidence: 99%

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

et al. 2020

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“…Nanotechnology is an advanced approach to produce nanoscale drug carriers with feasible potential for uniform delivery to mucosal tissue [ 12 , 13 , 14 ]. Previously published by our group data demonstrated that silver nanoparticles modified with tannic acid (TA-AgNPs) effectively reduced HSV-2 infectivity at the vaginal mucosal surface, suggesting a potential for nanoparticles as microbicide in HSV prevention [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Tannic Acid/Silver Nanoparticle-Based Mucoadhesive Hydrogel for Improved Local Treatment of HSV Infection: In Vitro and In Vivo Studies

Szymańska

Orłowski

Winnicka

et al. 2018

IJMS

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Mucoadhesive gelling systems with tannic acid modified silver nanoparticles were developed for effective treatment of herpes virus infections. To increase nanoparticle residence time after local application, semi solid formulations designed from generally regarded as safe (GRAS) excipients were investigated for their rheological and mechanical properties followed with ex vivo mucoadhesive behavior to the porcine vaginal mucosa. Particular effort was made to evaluate the activity of nanoparticle-based hydrogels toward herpes simplex virus (HSV) type 1 and 2 infection in vitro in immortal human keratinocyte cell line and in vivo using murine model of HSV-2 genital infection. The effect of infectivity was determined by real time quantitative polymerase chain reaction, plaque assay, inactivation, attachment, penetration and cell-to-cell assessments. All analyzed nanoparticle-based hydrogels exhibited pseudoplastic and thixotropic properties. Viscosity and mechanical measurements of hydrogels were found to correlate with the mucoadhesive properties. The results confirmed the ability of nanoparticle-based hydrogels to affect viral attachment, impede penetration and cell-to-cell transmission, although profound differences in the activity evoked by tested preparations toward HSV-1 and HSV-2 were noted. In addition, these findings demonstrated the in vivo potential of tannic acid modified silver nanoparticle-based hydrogels for vaginal treatment of HSV-2 genital infection.

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“…The pharmacokinetic profile of the nanoassemblies in tear fluid and aqueous humor showed increased absorption of the drug as compared to free drug solution. [87] Recently, five new molecules were synthesized and characterized for their capacity to form NP in water and to encapsulate ACV with high loading and sustained release. [88] The features of NP used in clinical therapeutics like US FDA-approved nanomedicines were characterized through various analytical methods for physicochemical characterization, sterility, pyrogenicity assessment, biodistribution (absorption, distribution, metabolism and excretion) and toxicity studies.…”

Section: Nanoparticulate Delivery Systemsmentioning

confidence: 99%

Drug delivery approaches of an antiviral drug: A comprehensive review

Durai¹

2015

Asian J Pharm

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T he guanine derivative antiviral drug acyclovir (ACV) is one of the oldest molecules laying successful market until date, being commercially available in various dosage forms for oral, topical and parenteral administrations. Clinical application of this drug is superior to new antiviral agents due to its potential values such as suppression of recurrence, safety profile, minimal drug interactions, and being inexpensive. ACV is slightly water-soluble, less permeable and poorly bioavailable, yet more potential antiviral molecule, the physicochemical modifications and novel dosage form approaches resulted with more than 100 research works within a decade. The survey of literature showed enormous reports on ACV formulation development, which includes modified tablets, particulate drug delivery, vesicular drug delivery, polymeric nanoparticles, bioadhesive systems, floating dosage forms, in situ gelling systems, transdermal delivery, implantable systems, emulsified dosage forms, polymeric films/patches, etc. As the drug could be administered via multiple routes for effective site targeted action at various doses, and attracted the attention of many researches, the review of the current approaches for the delivery of ACV could be more beneficial for the new scientists. This paper is a review of recent researches highlighting the development of newer techniques and novel dosage forms of ACV for better therapeutic efficacy, which were aimed at enhancing its solubility, permeability and bioavailability.Durai: Recent formulation designs of acyclovir How to cite this article: Durai RD. Drug delivery approaches of an antiviral drug: A comprehensive review. Asian J Pharm 2015;9:1-12.

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Nonpolymeric nanoassemblies for ocular administration of acyclovir: Pharmacokinetic evaluation in rabbits

Cited by 24 publications

References 41 publications

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

Assembling Surfactants-Mucoadhesive Polymer Nanomicelles (ASMP-Nano) for Ocular Delivery of Cyclosporine-A

Multifunctional Tannic Acid/Silver Nanoparticle-Based Mucoadhesive Hydrogel for Improved Local Treatment of HSV Infection: In Vitro and In Vivo Studies

Drug delivery approaches of an antiviral drug: A comprehensive review

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