Immunization can cause pain and trauma in children. One of the strategies to deal with immunization-related pain is combination between physical intervention and cognitive therapy called 5S method, which includes swaddling sidestomach, shushing, swinging, and sucking. This method involves some senses, such as sight, hearing, touch, taste, and touch, which can effectively decrease immunization pain. Research aims to determine the effects of 5S method (Swaddling, Side-Stomach, Shushing, Swinging, Sucking) on the pain scales in babies after immunization procedures. This study employed a quasi-experimental method with a post-test-only control group design. The samples included 60 babies that were recruited using a cluster random sampling technique. The babies in the intervention group (n=30) received the 5S method, while those in the control group (n=30) were carried and cuddled by their mothers to calm them down. The pain scale was measured using the FLACC scale after the intervention in each group. The Mann-Whitney U test was used for data analysis. In the intervention group, 17 babies (56.7%) experienced mild pain while in the control group, 20 babies (66.7%) experienced severe pain. The Mann-Whitney U test showed a p-value of 0.000 (p≤0.005). There was an effect of the 5S method (swaddling, side-stomach, shushing, swinging, sucking) on pain scales in babies after immunization procedures. The 5S method can be used easily for immunization procedures among babies in hospitals, public health centres, and integrated service posts.