“…It is important to note that the staining pattern seen in whole-mount preparations was identical using both ADPase enzyme histochemistry (Lutty and McLeod, 1992;Chan-Ling et al, 2004) and CD39 immunohistochemistry in the fetal human as a marker for angioblasts and blood vessels. It is present in adult retinal endothelial cells of all species studied to date and we have used it to study pathological neovascularization in sickle cell and diabetic retinopathy as well as retinopathy of prematurity McLeod, 1992, 2005;McLeod et al, 1993McLeod et al, , 1996bMcLeod et al, , 1997Lutty et al, 1994Lutty et al, , 1996. CD39, or nucleoside triphosphate diphosphohydrolase-1 (NTPDase1), is the major vascular endothelial ecto-nucleotidase and hydrolyses nucleoside triphosphates and diphosphates, ultimately to the nucleoside analogues (Goepfert et al, 2001).…”