Nonorganic and Organic Psychiatric Disorders in Patients after Epilepsy Surgery

Malmgren, Kristina; Je, Starmark; Ekstedt, Gerd; Rosén, Hans; Sjöberg-Larsson, C

doi:10.1006/ebeh.2001.0304

Cited by 42 publications

(28 citation statements)

References 29 publications

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“…The presence of postoperative psychiatric morbidity was significantly related to a preoperative history of anxiety and/or depressive disorder, but not to seizure outcome. 22 In the present follow-up, 29% of patients reported having had problems with depression and/or anxiety since the 2 year follow-up, again without any clear relation with seizure status. In a recent large prospective study, Devinsky et al found that seizure control was associated with a lower frequency of depression and anxiety disorders 2 years after resective epilepsy surgery.…”

Section: Discussionmentioning

confidence: 90%

“…We have previously described the 2 year outcome regarding alterations in seizure frequency, 20 general cognitive function, and memory 21 and psychiatric morbidity 22 in the first 70 consecutive operated adults. The aim of this study was to compare the long term (.10 years) outcome concerning seizure status, psychosocial issues and use of AED with the 2 year follow-up in these well characterised 70 adults.…”

Section: And Malmgren Et Al 5 )mentioning

confidence: 99%

“…Detailed data on the psychiatric morbidity in this patient cohort during the first 2 postoperative years have been published previously. 22 Apart from the structured telephone interview follow-up, patient files were available from routine clinical controls between the 2 year and long term follow-up. The information given in the interview on seizure status over time could therefore be compared with the clinical notes.…”

Section: Data Collectionmentioning

confidence: 99%

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Long term follow-up of the first 70 operated adults in the Goteborg Epilepsy Surgery Series with respect to seizures, psychosocial outcome and use of antiepileptic drugs

Asztély

Ekstedt

Rydenhag

et al. 2007

Journal of Neurology, Neurosurgery & Psychiatry

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Section: Discussionmentioning

confidence: 90%

Section: And Malmgren Et Al 5 )mentioning

confidence: 99%

Section: Data Collectionmentioning

confidence: 99%

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Long term follow-up of the first 70 operated adults in the Goteborg Epilepsy Surgery Series with respect to seizures, psychosocial outcome and use of antiepileptic drugs

Asztély

Ekstedt

Rydenhag

et al. 2007

Journal of Neurology, Neurosurgery & Psychiatry

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“…Psychiatric risk has been reported to be maximal in the first 1-3 months postsurgically [21][22][23].…”

Section: Risk Profile For Suicide In Epilepsymentioning

confidence: 98%

Epilepsy, antiepileptic drugs and suicidality

Bagary

2011

Current Opinion in Neurology

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The identification of risk factors such as mood or anxiety disorders in patients with epilepsy should not delay AED treatment as the risks associated with seizures far outweigh the current research evidence for increased AED-related suicide risk. A pragmatic approach to clinical assessment and management is suggested. Prospective AED trials should include validated scales to systematically identify neuropsychiatric complications of AEDs.

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“…[1][2][3][4][5][6]9,11,[13][14][15]17,19) These problems have recently become a focus of interest, as intractable epilepsy is recognized as a chronic encephalopathy in which one seizure induces other seizures. 7) Therefore, we need to analyze the overall effects on the quality of life to demonstrate the benefits of surgery.…”

Section: Introductionmentioning

confidence: 99%

Surgical Effects of Focus Resection for Patients With Intractable Epilepsy

Maehara

Inaji

2013

Neurol. Med. Chir.(Tokyo)

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Postoperative seizure-free outcome, psychiatric condition, intellectual function, and employment status were reviewed to demonstrate the usefulness of focus resection in 71 patients who underwent resective epilepsy surgery between 2000 and 2010 for the treatment of medication-resistant epilepsy. The psychiatric problems were assumed to be present only if the patient received psychotropic drug therapy. Seizure-free outcome was obtained in 53 (75%) patients. The patients were followed up for 2.0-12.0 years (mean 7.2 years) after surgery. Temporal lobe epilepsy (TLE), late seizure onset, short seizure duration, and magnetic resonance imaging lesions were all significantly associated with cessation of seizures. Psychotropic drug therapy was performed in 3 (4.2%) patients before surgery and in 12 (17.0%) patients at 2 years or later after surgery. TLE and preoperative psychotropic drugs were significantly associated with postoperative psychiatric problems. Among the 71 patients, 65 underwent full Wechsler Adult Intelligence Scale-Revised (WAIS-R) examinations both before and after surgery. The mean WAIS-R score was 82.5 ± 18.7 points for total intelligence quotient (IQ) preoperatively and 89.6 ± 20.3 points for total IQ postoperatively. Before surgery, 19 (27%) patients were engaged in full-time employment. After surgery, 2 patients lost and 9 patients newly entered full-time employment, so a total of 26 (37%) patients were engaged in full-time employment after surgery. Resective epilepsy surgery resulted in overall improvements in seizure control, intellectual functions, and employment status. However, patients with TLE had some risk of postoperative psychiatric disorder.

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Nonorganic and Organic Psychiatric Disorders in Patients after Epilepsy Surgery

Cited by 42 publications

References 29 publications

Long term follow-up of the first 70 operated adults in the Goteborg Epilepsy Surgery Series with respect to seizures, psychosocial outcome and use of antiepileptic drugs

Long term follow-up of the first 70 operated adults in the Goteborg Epilepsy Surgery Series with respect to seizures, psychosocial outcome and use of antiepileptic drugs

Epilepsy, antiepileptic drugs and suicidality

Surgical Effects of Focus Resection for Patients With Intractable Epilepsy

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