Nonoperative Options for Management of Articular Cartilage Disease

Poddar, Sourav; Widstrom, Luke

doi:10.1016/j.csm.2017.02.003

Cited by 12 publications

(4 citation statements)

References 51 publications

(58 reference statements)

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“…By addressing obesity and promoting weight loss, non‐surgical methods play a crucial role in managing symptoms and preserving the functionality of cartilage. While they cannot restore damaged cartilage completely, these interventions have shown promising effects in improving the overall condition of individuals with cartilage‐related issues 38 …”

Section: Cartilage Injuries and Repairmentioning

confidence: 99%

Magnetic hydrogel applications in articular cartilage tissue engineering

Taghizadeh,

Tayebi,

Akbarzadeh

et al. 2023

J Biomedical Materials Res

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Articular cartilage defects afflict millions of individuals worldwide, presenting a significant challenge due to the tissue's limited self‐repair capability and anisotropic nature. Hydrogel‐based biomaterials have emerged as promising candidates for scaffold production in artificial cartilage construction, owing to their water‐rich composition, biocompatibility, and tunable properties. Nevertheless, conventional hydrogels typically lack the anisotropic structure inherent to natural cartilage, impeding their clinical and preclinical applications. Recent advancements in tissue engineering (TE) have introduced magnetically responsive hydrogels, a type of intelligent hydrogel that can be remotely controlled using an external magnetic field. These innovative materials offer a means to create the desired anisotropic architecture required for successful cartilage TE. In this review, we first explore conventional techniques employed for cartilage repair and subsequently delve into recent breakthroughs in the application and utilization of magnetic hydrogels across various aspects of articular cartilage TE.

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Section: Cartilage Injuries and Repairmentioning

confidence: 99%

Magnetic hydrogel applications in articular cartilage tissue engineering

Taghizadeh,

Tayebi,

Akbarzadeh

et al. 2023

J Biomedical Materials Res

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“…Non-surgical conservative treatment and drug (painkillers and NSAIDs) therapy can effectively relieve pain in the early stages of articular cartilage lesion but cannot reverse cartilage degeneration defect ( Poddar and Widstrom, 2017 ). Transplantation (using allogeneic or autologous cells or tissues) and stimulation (stimulating self-repair of articular cartilage) are commonly used in the late treatment of OA ( Tuan et al, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Advanced injectable hydrogels for cartilage tissue engineering

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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The rapid development of tissue engineering makes it an effective strategy for repairing cartilage defects. The significant advantages of injectable hydrogels for cartilage injury include the properties of natural extracellular matrix (ECM), good biocompatibility, and strong plasticity to adapt to irregular cartilage defect surfaces. These inherent properties make injectable hydrogels a promising tool for cartilage tissue engineering. This paper reviews the research progress on advanced injectable hydrogels. The cross-linking method and structure of injectable hydrogels are thoroughly discussed. Furthermore, polymers, cells, and stimulators commonly used in the preparation of injectable hydrogels are thoroughly reviewed. Finally, we summarize the research progress of the latest advanced hydrogels for cartilage repair and the future challenges for injectable hydrogels.

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“…Consequently, the nonoperative measures are an optimal option for most patients with chronic knee pain, such as functional motion, reducing weight, pain killers, and corticosteroid injections. However, current evidence did not prove which one of those nonoperative therapies should be recommended as the first-line therapy based on comprehensive and individualized consideration of the adverse impacts and positive outcomes of patients [7]. Complementary therapy such as ginger in the management of chronic knee pain has been fully discussed in recent studies [8,9].…”

Section: Introductionmentioning

confidence: 99%

Current Evidence Does Support the Use of KT to Treat Chronic Knee Pain in Short Term: A Systematic Review and Meta-Analysis

Luo

2021

Pain Research and Management

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Objective. To demonstrate whether KT is better than placebo taping, nonelastic taping, or no taping in reducing pain. Methods. PubMed, Embase, Web of Science, the Cochrane Central Library, and ClinicalTrials.gov were systematically searched up to 20 October 2020 for randomized controlled studies that used KT to treat chronic knee pain according to PRISMA guidelines. We extracted the mean differences and SD in pretreatment and posttreatment for selected outcomes measured in the experimental and control groups for subsequent meta-analyses. Results. In total, 8 studies involving 416 participants fulfilled the inclusion criteria. Our results indicated that KT is better than other tapings (placebo taping or nonelastic taping) in the early four weeks. The mean difference was −1.44 (95% CI: −2.04–−0.84, I2 = 49%, P ≤ 0.01 ). Treatment methods which were performed for more than six weeks (0.16 (95% CI: −0.35–0.68, I2 = 0%, P = 0.53 )) show no significant difference in reducing pain. In studies in which visual analogue scale was measured, a positive effect was observed for KT combined with exercise program training (−3.27 (95% CI: −3.69–2.85, I2 = 0%, P < 0.05 )). Conclusion. KT exhibited significant but temporary pain reduction.

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Nonoperative Options for Management of Articular Cartilage Disease

Cited by 12 publications

References 51 publications

Magnetic hydrogel applications in articular cartilage tissue engineering

Magnetic hydrogel applications in articular cartilage tissue engineering

Advanced injectable hydrogels for cartilage tissue engineering

Current Evidence Does Support the Use of KT to Treat Chronic Knee Pain in Short Term: A Systematic Review and Meta-Analysis

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