Nonneoplastic findings in loop electrical excision procedure specimens from patients with persistent atypical squamous cells of uncertain significance in two consecutive pap smears

Abstract

The present study aimed to determine the histopathological correspondence of the diagnosis of atypical squamous cells of uncertain significance (ASCUS) in the absence of squamous intraepithelial neoplasia (SIL) in loop electrical excision procedure (LEEP) products. Retrospective histopathological analysis of 70 LEEP products preceded by ASCUS was consistently detected by two consecutive Pap smears. The presence or absence of several histopathological findings in cases with (23/70) and without (47/70) histological diagnosis of SIL were compared. Immature squamous metaplasia, severe cervicitis, and tube-endometrial metaplasia were found with similar frequency on positive and negative neoplastic disease specimens. Reactive squamous atypia, keratosis, atrophy, glandular reactive/inflammatory atypia, tunnel clusters, and microglandular hyperplasia were less frequently found in LEEP specimens presenting with SIL. Reactive squamous atypia and keratosis were consistently associated with SIL absence and appear to be responsible for the cytological diagnosis of ASCUS (P < 0.05).

Cervical cancer screening program of Paraná: Cytohistological correlation results after five years

“…23 By the other hand, when intraepithelial lesions were absent in the LEEP products, histological findings as reactive squamous atypia and keratosis were pointed as possible causes for the cytological abnormalities. 24 Because of the uncertainty of this diagnosis and the high degree of correlation with the presence of intraepithelial lesions, these cases should always be sent for colposcopy.…”

Clinical efficacy of agonist toll-like receptor 9 on the process of reparations after loop conization (LEEP) of the cervix

“…Таким образом, индуцированная агонистом TLR9 (дезоксирибонуклеат натрия) стимуляция репаративной регенерации тканей шейки мат-ки после LEEP предположительно происходит в результате направленной модификации фе-нотипа резидентных макрофагов в зоне после-операционной альтерации [19]. Этим процес-сом можно объяснить ускоренное, в среднем на 6-7 суток, заживление послеоперационной раны с отторжением струпа в группе, полу-чавшей лечение иммунорепарантом Деринат по сравнению с группой, не получавшей меди-каментозной терапии после LEEP (см.…”

“…При этом наиболее активиро-ванными оказываются именно резидентные макрофаги в очаге альтерации. Именно у этих макрофагов отмечается наибольшая экспрес-сия TLR9, и они становятся наиболее чувстви-тельными к стимуляции препаратами-агони-стами [19,20], в частности препаратом Деринат.…”

Variantes de lesões intra-epiteliais escamosas: relato de quatro casos

“…Em pesquisa realizada anteriormente, investigando a correlação cito-histológica de casos caracterizados citologicamente como atípicos de significado indeterminado (ASCUS), alguns casos foram identificados (19) . Estima-se que até 10% das lesões caracterizadas como intra-epiteliais de alto grau (LIAG) podem se tratar de variantes de difícil caracterização morfológica (4) .…”