Nonmyeloablative allogeneic bone marrow transplantation for orbital granulocytic sarcoma associated with t(8;21)(q22;q22) in acute myeloid leukemia

Gy, Hung; Tj, Chiou; Hsieh, Y-L; Pm, Chen; Hwang, Betau

doi:10.1038/sj.bmt.1703316

Cited by 12 publications

(5 citation statements)

References 12 publications

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“…AML, characterized by the aberrant proliferation of myeloid stem cells, reduced apoptosis and blockage in cellular differentiation, is usually associated with a complex translocation, e.g. t(8;21)(q22;q22) with other complex variants and the transcription factor fusion protein, RUNX1-RUNX1T1 (also known as AML1-ETO) [2,3,4]. GS has been reported to be associated with t(8;21) translocation and can present either before, concurrent with or after the onset of AML.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Factors of Treatment Outcomes in Patients with Granulocytic Sarcoma

Lan¹,

et al. 2009

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Purpose: To investigate the possible prognostic factors of survival outcomes in patients with granulocytic sarcoma (GS). Methods: We retrospectively investigated the prognostic factors determining survival in 24 patients with GS using Kaplan-Meier survival analysis followed by log rank tests. We evaluated gender, age, location, GS antedating leukemia, underlying disorders, treatment type and stem cell transplantation. Results: The 5-year survival rate for the patients with GS was 21%. The patients undergoing chemotherapy had a significantly longer survival time compared to those who did not (p = 0.0009). We found no difference in the 5-year survival rate among the patients undergoing chemotherapy combined with radiation or surgery. Patients with chronic myelogenous leukemia and myelodysplastic disorders had worse survival rates (p = 0.0028). Conclusion: Early diagnosis with biopsy and early chemotherapy can improve survival outcome. Local radiation or surgery can improve symptoms but does not influence survival outcomes.

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Section: Introductionmentioning

confidence: 99%

Prognostic Factors of Treatment Outcomes in Patients with Granulocytic Sarcoma

Lan¹,

et al. 2009

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“…In addition to the AMKL patient reported in this article, 103 cases of extramedullary AML at the time of initial diagnosis in pediatric patients were found in the English-language literature (102 cases) from 1971–2011 and in the archives of Children's Hospital Colorado (1 case) from 1990–2011. Of these, 9 cases were AMKL [5–8,10] and 94 cases were non-AMKL [11–77]. Nineteen of the 94 non-AMKL pat...…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological Characteristics of Extramedullary Acute Megakaryoblastic Leukemia (AMKL): Report of a Case with Initial Mastoid Presentation and Review of Literature to Compare Extramedullary AMKL and Non-AMKL Cases

2012

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Extramedullary acute megakaryoblastic leukemia (AMKL) is a rare neoplasm with a varied clinical presentation. AMKL with initial mastoid presentation has never been reported. The extreme rarity of mastoid AMKL, together with the tendency of extramedullary AMKL to mimic other small blue cell tumors, can create a diagnostic challenge. We report a case of AMKL that initially presented as a mastoid lesion and provide a comprehensive review and analysis that compares the characteristics of extramedullary AMKL and nonmegakaryoblastic acute myeloid leukemia (AML) in reported pediatric cases over the past 30 years. We found that patients with extramedullary AMKL were not only younger than patients without megakaryocytic differentiation but were also limited to those ≤ 2 years of age. In addition, girls predominated in both AMKL and AML MLL(+) groups compared with other types of AML (P = 0.0366 and P = 0.0082). Furthermore, we found that extramedullary AMKL was more likely to involve bone than AML MLL(+) (P < 0.0001) or other types of AML (P = 0.0002). These findings suggest that extramedullary AMKL should be considered in the differential diagnosis of SBCT in children, especially in patients with mastoid or other bony lesions, those ≤ 2 years of age, and female patients.

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“…Previous reports have described patients with chemoresistant MS or MS with an unfavorable prognosis who were treated with allo-HCT (5-11). In some cases involving a large mass or multiple lesions, long-term survival was achieved by performing the transplant with the patient in a non-CR state; however, these lesions make accurate evaluation of the extent of any residual disease remaining after chemotherapy difficult (7)(8)(9). On the other hand, some case reports demonstrated that MS relapsed after allo-HCT for leukemia (12,13).…”

Section: Discussionmentioning

confidence: 99%

Successful Treatment of Duodenal Myeloid Sarcoma with Allogeneic Bone Marrow Transplantation and Additional Radiotherapy

et al. 2012

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Myeloid sarcoma (MS) is a tumor consisting of myeloid blasts that occurs at an anatomical site other than the bone marrow. We report the case of a 38-year-old man with duodenal MS who underwent an allogeneic bone marrow transplant in a non-complete remission (CR) state. After the transplant, residual disease was suspected on a fluorodeoxyglucose positron emission tomography (FDG-PET)/CT scan, and additional radiotherapy resulted in CR, which has been maintained for 21 months. FDG-PET/CT scanning is useful for evaluating residual myeloid sarcoma during the peritransplant period.

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Nonmyeloablative allogeneic bone marrow transplantation for orbital granulocytic sarcoma associated with t(8;21)(q22;q22) in acute myeloid leukemia

Cited by 12 publications

References 12 publications

Prognostic Factors of Treatment Outcomes in Patients with Granulocytic Sarcoma

Prognostic Factors of Treatment Outcomes in Patients with Granulocytic Sarcoma

Clinicopathological Characteristics of Extramedullary Acute Megakaryoblastic Leukemia (AMKL): Report of a Case with Initial Mastoid Presentation and Review of Literature to Compare Extramedullary AMKL and Non-AMKL Cases

Successful Treatment of Duodenal Myeloid Sarcoma with Allogeneic Bone Marrow Transplantation and Additional Radiotherapy

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