Nonmelanotic Pigmentary Disorders with Abnormal Deposits

Dermatosis Neglecta Based on Exanthematous Drug Eruption Following Head Trauma: A Case Report and Literature Review

“…The diagnosis in this patient requires differentiation from acanthosis nigricans, Darier's disease, Terra Firme-Forme Dermatosis, and confluent and reticulated papillomatosis. 11 The occurrence of DN after trauma has been previously reported, as was the case in our patient. The patient's jaw and oral cavity were damaged when he was young, but DN did not occur at that time, which may be related to the faster skin metabolism and stronger repair ability of young people.…”

“…13 Our patient's rash was consistent with an exanthematous drug eruption with a Naranjo score of 6, 14 indicating that vancomycin was most likely the causative agent of the patient's drug eruption. Patients with autoimmune diseases have a high incidence of drug allergy, such as Sjogren's syndrome, systemic lupus erythematosus, and adult-onset Still's disease, 11 additionally DN could be accompanied by Sjogren's syndrome, 4 several autoantibodies were positive in this patient, and connective tissue disease could not be excluded after consultation with the rheumatology department, because the patient had no symptoms, such as the dry mouth and eyes, oral ulcers, joint pain, and photaesthesia, thus he could not be further diagnosed. The relationship between a patient's autoantibody and drug eruptions, DN, or both remains uncertain.…”