Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas

Wood, Gary S.; Gunkel, Juliet; Stewart, Daniel P.; Gordon, Ellen M.; Bagheri, Mamad M.; Gharia, Manish; Snow, Stephen N.

doi:10.1016/b978-0-443-06694-8.50078-6

Cited by 9 publications

(14 citation statements)

References 213 publications

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“…Ulceration, edema, pain, and bleeding occur, especially once the tumor exceeds 10 cm in diameter. 6 While our patient had the most common historical presentation of CA, the idiopathic angiosarcoma of the face and scalp associated with extensive actinic damage, the clinical morphology of her tumor was more consistent with that of a morpheaform basal cell carcinoma. She did not exhibit the overt violaceous, ecchymotic plaques and nodules that are typically demonstrated in this form of angiosarcoma.…”

Section: Discussionmentioning

confidence: 59%

“…Initially, it may present as erythematous to violaceous macules or plaques with small adjacent nodules, which may be confused clinically with ecchymoses, hemangiomas, inflammatory changes, cellulitis, fungal infections, and even rosacea. [4][5][6] CA can rapidly progress, transforming into large, grayish-to-white masses that spread subcutaneously beyond their clinical appearance. As the tumors grow, they often become multifocal, which may complicate definition of tumor margins.…”

Section: Discussionmentioning

confidence: 99%

“…Our patient's tumor displayed an angiomatous pattern characterized by well to moderately differentiated, dilated well-defined vascular spaces lined by single to multiple layers of dense hyperchromatic, atypical endothelial cells. [6][7][8][9][10] These vascular spaces dissect through dense connective tissue, but do not invade adjacent adnexal structures.…”

Section: Discussionmentioning

confidence: 99%

“…2,7,14,15,19 Mohs micrographic surgery is another possible surgical option, but adjunctive therapy with radiation is often necessary because of multifocal subcutaneous spread. 6,20 Other treatment modalities include radiation alone, chemotherapy, interleukin-2, and interferon, but unfortunately these options have been relatively unsuccessful. [2][3][4]13 Patients must be followed closely every 3 months with lymph node palpation and complete cutaneous examinations.…”

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Angiosarcoma Clinically Resembling Morpheaform Basal Cell Carcinoma

Kasper¹,

Smetanick

Ermolovich

2008

Dermatologic Surgery

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Section: Discussionmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Angiosarcoma Clinically Resembling Morpheaform Basal Cell Carcinoma

Kasper¹,

Smetanick

Ermolovich

2008

Dermatologic Surgery

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“…Intracellular signaling deregulated pathways in SCC pinpoint to p53 pathway as mutated p53 is the most common genetic abnormality found in SCC. AK lesions can harbor mutated p53, and remain as such through the malignization process toward SCC [15,16]. Whole transcriptome analysis published in 2016 has shown in SCC cancer cells, in comparison to normal human epidermal keratinocytes, an overexpression of long intergenic non coding RNA (LINC00162).…”

Section: Squamous Cell Carcinomamentioning

confidence: 99%

Photosensitizers Imprinting Intracellular Signaling Pathways in Dermato-Oncology Therapy

Constantin¹,

Neagu²

2017

Photomedicine - Advances in Clinical Practice

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This chapter describes the main deregulated intracellular pathways at both genetic and proteomic levels that are found in three main skin cancers: basal cell carcinoma, squamous cell carcinoma and melanoma. In basal cell carcinoma, the main intracellular signaling pathways is the Sonic Hedgehog pathway, while in squamous cell carcinoma, it is the p53 pathway. However, in both nonmelanoma skin cancers, these major pathways trigger cross-activation with other important ones. In melanoma, mitogen-activated protein kinase pathway and PI3K/Akt pathways are deeply deregulated, and moreover due to the disease complexity, BRAF, RAS (N/H/K), NF1 and Triple-WT melanoma subtypes need additional molecular stratification. The stage in which photodynamic therapies' clinical application is in the treatment of these diseases is another subject tackled by the chapter. Thus, if basal cell carcinoma and squamous cell carcinoma possess in their therapeutical armamentarium photodynamic therapies approach, melanoma, with its particularities, still needs thorough molecular investigations to adapt this particular therapy. Based on the accumulated knowledge on pathological intracellular pathways, the chapter describes the molecular details that reside in applying photodynamic therapy. In vivo and in vitro models of cutaneous malignancy and photodynamic therapies' molecular events are further detailed.

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Outpatient Nonmelanoma Skin Cancer Excision and Reconstruction: A Clinical, Economical, and Patient Perception Analysis

Lisa

Vinci

Galtelli

et al. 2022

Plastic and Reconstructive Surgery - Global Open

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Background: Nonmelanoma skin cancers constitute more than 15% of all types of cancer. To obtain the best cosmetic outcome, local flaps represent the ideal surgical choice. Methods: We conducted a retrospective review of patients treated from 2016 to 2019. The day-surgery group included 73 patients, and the outpatient group included 70 patients. We analyzed medical records regarding age of diagnosis, waiting time, site of lesion, reconstructive technique, histologic diagnosis, radicality of excision, and complications. We administered a survey based on quality items and carried out an economic evaluation. Results: Outpatient removals were radical 92.6% of the time against the 78% of those performed in the operating room ( P = 0.14). We observed two cases of wound dehiscence and two cases of hematoma in the day-surgery group. Economic analysis showed reduced costs in the outpatient setting. Conclusion: Skin excision and local flap reconstruction are safe procedures in an outpatient setting under a clinical, economical, and patient perception point of view.

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Nonmelanoma Skin Cancers: Basal Cell and Squamous Cell Carcinomas

Cited by 9 publications

References 213 publications

Angiosarcoma Clinically Resembling Morpheaform Basal Cell Carcinoma

Angiosarcoma Clinically Resembling Morpheaform Basal Cell Carcinoma

Photosensitizers Imprinting Intracellular Signaling Pathways in Dermato-Oncology Therapy

Outpatient Nonmelanoma Skin Cancer Excision and Reconstruction: A Clinical, Economical, and Patient Perception Analysis

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