Nonmelanoma skin cancer treated with electronic brachytherapy: Results at 1 year

Bhatnagar, Ajay

doi:10.1016/j.brachy.2012.08.003

Cited by 77 publications

(77 citation statements)

References 20 publications

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“…The first two (nonmelanoma) are occurring on the outer layer of skin (epidermis) 1 , 2 , 3 . Melanoma occurs on the skin at the palm of hands and soles of feet, scalp, ears, nails, and back, and may turn the skin color to black (melanin).…”

Section: Introductionmentioning

confidence: 99%

“…In 2015, approximately 74,000 Americans will be diagnosed with stage I‐IV melanoma, which led approximately to 10,000 deaths (1) . Nonmelanoma skin cancer affects approximately two to three million people each year in the United States (3) . However, that has a lower mortality rate (less than 1000) and it significantly affects the quality of life (2) .…”

Section: Introductionmentioning

confidence: 99%

“…In radiation therapy, X‐rays or electron beams may be used to treat local skin cancers. A variety of radiation therapy techniques are used including superficial X‐rays, (4) orthovoltage X‐rays, (5) megavoltage photons, (4) electron beam therapy, (4) and brachytherapy 2 , 3 , 6 , 7 . Several groups have shown different percentages of tumor control results for nonmelanoma skin cancer treatment using superficial X‐rays with 93%–100%, (4) orthovoltage X‐rays with 87%, (8) electron beams with 72%–88%, (4) isotope‐based HDR brachytherapy with 92%–98%, (6) and 100% for eBT up to 2013 (6) …”

Section: Introductionmentioning

confidence: 99%

“…Generally for external electron beam therapy, a protocol with about 40 Gy to 60 Gy total dose is delivered at the rate of 2 Gy to 3 Gy per fractions within four to six weeks 4 , 6 . However, for brachytherapy, skin treatment by IR‐HDRs and eBT, the patient receives 6 to 8 fractions for a total dose ranging from 30 Gy to 40 Gy in two weeks 3 , 7 , 9 , 10 , 11 . Normally, all of these treatments are performed assuming homogenous tissue condition and ignoring the underlying bone.…”

Section: Introductionmentioning

confidence: 99%

“…The main component of these systems is a miniature X‐ray tube that produces the bremsstrahlung radiation using electron energies ranging from 20 to 70 keV. Treatment of skin cancer by the eBT systems can be performed using the conical applicators that have been developed by the manufacturer 3 , 7 . Four eBT applicator sizes are available with diameters of 1 cm, 2 cm, 3.5 cm, and 5 cm.…”

Section: Introductionmentioning

confidence: 99%

See 4 more Smart Citations

Optimum radiation source for radiation therapy of skin cancer

Safigholi

Song

Meigooni

2015

J Applied Clin Med Phys

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Several different applicators have been designed for treatment of skin cancers, such as scalp, hand, and legs using Ir‐192 HDR brachytherapy sources (IR‐HDRS), miniature electronic brachytherapy sources (eBT), and external electron beam radiation therapy (EEBRT). Although, all of these methodologies may deliver the desired radiation dose to the skin, but the dose to the underlying bone may become the limiting factor for selection of the optimum treatment technique. In this project, dose to the underlying bone has been evaluated as a function of the radiation type, thickness of the bone, and thickness of the soft tissue on top of bone, assuming the same radiation dose delivery to the skin. These evaluations are performed using Monte Carlo (MC) simulation technique with MCNP5 code. The results of these investigations indicate that, for delivery of the same skin dose with a 50 keV eBT, 4 MeV or 6 MeV EEBRT techniques, the average doses received by the underlying bones are 5.31, 2, or 1.75 times the dose received from IR‐HDRS technique, respectively. These investigations indicate that, for the treatment of skin cancer condition with bone immediately beneath skin, the eBT technique may not be the most suitable technique, as it may lead to excessive bone dose relative to IR‐HDRS and 6 MeV or 4 MeV electron beams.PACS number: 87.53.Jw, 87.55.K‐

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Optimum radiation source for radiation therapy of skin cancer

Safigholi

Song

Meigooni

2015

J Applied Clin Med Phys

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A Sudden and Concerning Increase in the Use of Electronic Brachytherapy for Skin Cancer

2015

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Local Recurrence and Ocular Adnexal Complications Following Electronic Surface Brachytherapy for Basal Cell Carcinoma of the Lower Eyelid

Eftekhari¹,

Anderson²,

Suneja

et al. 2015

JAMA Dermatol

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onmelanoma skin cancer (NMSC) affects over 2 million individuals per year in the United States. 1 A variety of modalities exist to treat basal cell carcinoma (BCC) and squamous cell carcinoma lesions, including electrodessication and curettage, excision, Mohs micrographic surgery, and topical agents. Radiation therapy is an alternative treatment option in select cases and can be delivered via different modalities, including external-beam radiation with megavoltage photons, superficial radiographs, electrons, or surface mold brachytherapy. 2 Recently, others have reported using high dose rate electronic surface brachytherapy (ESB) as an alternative treatment option for NMSC. 2,3 Purported advantages of this technique over standard external beam radiation therapy include less shielding and fewer treatment visits owing to the hypofractionated regimen, which delivers a larger dose per treatment with fewer overall treatments. Although good shortterm efficacy and cosmesis have been reported with ESB by others, the long-term safety and efficacy of this treatment modality remains unknown. 2,4 Herein, we report a case of BCC treated with ESB that recurred within 1 year of treatment within the radiation field, and in which the patient experienced lower eyelid ectropion and socket contracture leading to displacement of his ocular prosthesis.

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Nonmelanoma skin cancer treated with electronic brachytherapy: Results at 1 year

Cited by 77 publications

References 20 publications

Optimum radiation source for radiation therapy of skin cancer

Optimum radiation source for radiation therapy of skin cancer

A Sudden and Concerning Increase in the Use of Electronic Brachytherapy for Skin Cancer

Local Recurrence and Ocular Adnexal Complications Following Electronic Surface Brachytherapy for Basal Cell Carcinoma of the Lower Eyelid

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