Opioid Analgesic Misuse in a Community-Based Cohort of HIV-Infected Indigent Adults O pioid analgesic misuse has risen in conjunction with increased rates of opioid prescribing. The association may be due to increased misuse among individuals receiving prescribed opioids or among those acquiring diverted opioids. 1 Individuals with pain and co-occurring mental health or substance use disorders are at an increased risk for misuse. 2,3 Despite guidelines recommending caution, 4 health care providers prescribe opioids to individuals with these disorders at higher rates than they do to individuals without them. 5 Few studies have examined misuse among highrisk, community-based populations. We conducted a longitudinal study of a community-sampled cohort of human immunodeficiency (HIV)-infected indigent adults, selected without regard to pain status or receipt of prescribed opioids, to examine rates of and factors associated with opioid analgesic misuse. Methods. We recruited participants from the Research on Access to Care in the Homeless (REACH) study, a longitudinal cohort of indigent HIV-infected adults in San Francisco recruited via community-based probability sampling. 6 We interviewed participants at a communitybased field site quarterly for 2 years about pain, treatment for pain, alcohol use, current smoking, illicit substance use, and depression. We described methods and study variables previously. 7,8 At each interview, participants self-reported opioid analgesic misuse behaviors using audio computer assisted self-interviewing (ACASI) technology. We asked participants to report whether their motivation for misuse was to "treat pain," "get high," both, or neither. We defined major opioid analgesic misuse as behaviors that posed imminent risk for overdose or legal peril, or behaviors for which more than 50% of the participants reported their motivation for the behavior was to get high (Table). We reported past 90day rates of misuse at the enrollment interview and cumulative rates over the study interval. Using mixedeffects multivariate logistic regression, we determined factors associated with major misuse.