Nonmammalian Parent-of-Origin Effects

Casa-Esperón, Elena de la

doi:10.1007/978-1-62703-011-3_19

Cited by 7 publications

(2 citation statements)

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“…In this study, we show genome-wide parent-of-origin expression in an insect whereby maternally inherited chromosomes are the main contributors to transcriptomic activity in males. In recent years, a number of studies have considered genomic imprinting beyond mammals and flowering plants ( de la Casa-Esperón 2012 ; MacDonald 2012 ). We now have several allele-specific studies of imprinted gene expression (or lack thereof) in insects ( Coolon et al.…”

Section: Discussionmentioning

confidence: 99%

Males That Silence Their Father’s Genes: Genomic Imprinting of a Complete Haploid Genome

Filia

Mongue

Dorrens

et al. 2021

Molecular Biology and Evolution

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Genetic conflict is considered a key driver in the evolution of reproductive systems with non-Mendelian inheritance, where parents do not contribute equally to the genetic makeup of their offspring. One of the most extraordinary examples of non-Mendelian inheritance is paternal genome elimination (PGE), a form of haplodiploidy which has evolved repeatedly across arthropods. Under PGE, males are diploid but only transmit maternally-inherited chromosomes, while the paternally-inherited homologues are excluded from sperm. This asymmetric inheritance is thought to have evolved through an evolutionary arms race between the paternal and maternal genomes over transmission to future generations. In several PGE clades, such as the mealybugs (Hemiptera: Pseudococcidae), paternal chromosomes are not just eliminated from sperm, but also heterochromatinised early in development and thought to remain inactive, which could result from genetic conflict between parental genomes. Here, we present a parent-of-origin allele-specific transcriptome analysis in male mealybugs showing that expression is globally biased towards the maternal genome. However, up to 70% of somatically-expressed genes are to some degree paternally-expressed, while paternal genome expression is much more restricted in the male reproductive tract, with only 20% of genes showing paternal contribution. We also show that parent-of-origin-specific gene expression patterns are remarkably similar across genotypes, and that genes with completely biparental expression show elevated rates of molecular evolution. Our results provide the clearest example yet of genome-wide genomic imprinting in insects and enhance our understanding of PGE, which will aid future empirical tests of evolutionary theory regarding the origin of this unusual reproductive strategy.

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Section: Discussionmentioning

confidence: 99%

Males That Silence Their Father’s Genes: Genomic Imprinting of a Complete Haploid Genome

Filia

Mongue

Dorrens

et al. 2021

Molecular Biology and Evolution

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“…A positive correlation between number of crossovers and SC length has also been observed between different inbred strains of mice (Baier et al 2014;Lynn et al 2002). These intraspecific studies suggest that genetic differences, as well as chromatin packaging changes, underlie differences in crossover frequency (Baier et al 2014;de la Casa-Esperon 2012;de la Casa-Esperon and Sapienza 2003;Kleckner 2006;Kleckner et al 2003). Among the few loci identified in mice that control recombination rate (Balcova et al 2016;Baudat et al 2010;de la Casa-Esperon et al 2002;Myers et al 2010;Parvanov et al 2010), Prdm9 codes for a histone methyltransferase that determines recombination hotspots.…”

Section: Introductionmentioning

confidence: 92%

Diet effects on mouse meiotic recombination: a warning for recombination studies

et al. 2021

Preprint

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Meiotic recombination is a critical process for sexually reproducing organisms. This exchange of genetic information between homologous chromosomes during meiosis is important not only because it generates genetic diversity, but also because it is often required for proper chromosome segregation. Consequently, the frequency and distribution of crossovers are tightly controlled to ensure fertility and offspring viability. However, in many systems it has been shown that environmental factors can alter the frequency of crossover events. Two studies in flies and yeast point to nutritional status affecting the frequency of crossing over. However, this question remains unexplored in mammals. Here we test how crossover frequency varies in response to diet in Mus musculus males. We use immunohistochemistry to estimate crossover frequency in multiple genotypes under two diet treatments. Our results indicate that while crossover frequency was unaffected by diet in some strains, other strains were sensitive even to small composition changes between two common laboratory chows. Therefore, recombination is both resistant and sensitive to certain dietary changes in a strain-dependent manner and, hence, this response is genetically determined. Our study is the first to report a nutrition effect on genome-wide levels of recombination. Moreover, our work highlights the importance of controlling diet in recombination studies and may point to diet as a potential source of variability among studies, which is relevant for reproducibility.

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Genomic Imprinting in Mammals: Origin and Complexity of an Epigenetically Regulated Phenomenon

Casa-Esperón

2017

Gene Regulation, Epigenetics and Hormone Signaling

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Nonmammalian Parent-of-Origin Effects

Cited by 7 publications

References 93 publications

Males That Silence Their Father’s Genes: Genomic Imprinting of a Complete Haploid Genome

Males That Silence Their Father’s Genes: Genomic Imprinting of a Complete Haploid Genome

Diet effects on mouse meiotic recombination: a warning for recombination studies

Genomic Imprinting in Mammals: Origin and Complexity of an Epigenetically Regulated Phenomenon

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