Nonmalignant Thoracic Disorders

Dhingra, Vandana; Khan, Dikhra; Kumar, Rakesh; Basu, Sandip

doi:10.1016/j.cpet.2022.03.008

Cited by 2 publications

(3 citation statements)

References 64 publications

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“…The increased uptake of FDG by increased glycolysis and metabolism in cancer cells is a basis for the detection of malignant lesions in PET/CT 5,6 . From that basis for the uptake, PET/CT can be also utilized for inflammatory diseases such as cardiac sarcoidosis in addition to the detection of cancers 7–10 . An increased blood flow into a malignant tumor is also a basis for detection by contrast‐enhanced CT using iodinated medium.…”

Section: Discussionmentioning

confidence: 99%

“…5,6 From that basis for the uptake, PET/CT can be also utilized for inflammatory diseases such as cardiac sarcoidosis in addition to the detection of cancers. [7][8][9][10] An increased blood flow into a malignant tumor is also a basis for detection by contrastenhanced CT using iodinated medium. The uptake of thallium-201 is partially dependent on blood flow and the sodium-potassium adenosine triphosphatase system, which has a different kinetics of FDG by the uptake due to glycolysis.…”

Section: Discussionmentioning

confidence: 99%

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The potential value of thallium‐201 scintigraphy in the diagnosis of squamous cell carcinoma arising from extensive pyoderma

Namiki

Makiguchi

Wada

et al. 2023

The Journal of Dermatology

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Squamous cell carcinoma (SCC) arises from a variety of premalignant conditions, including pyoderma. However, an accurate diagnosis of SCC is sometimes challenging due to indistinguishable inflammatory lesions. Here, we present a case of SCC arising from extensive pyoderma, which was successfully diagnosed by taking advantage of thallium‐201 scintigraphy. A 49‐year‐old man presented with an elevated tumor on his right buttock. Computed tomography (CT) and enhanced magnetic resonance imaging (MRI) identified the tumor, but many indistinguishable lesions were also found around the tumor. Histopathology revealed an atypical proliferation of keratinocytes with cancer pearls inside the tumor nests, while histopathology of nodules around the tumor revealed inflammatory tissues. Positron emission tomography CT (PET/CT) revealed an accumulation of 2‐deoxy‐2‐[18F]‐D‐glucose at the axillae and inguinal nodes, and at subcutaneous tissues in addition to the tumor. From the CT, enhanced MRI, and PET/CT analyses it was impossible to differentiate many scattered subcutaneous nodules on the trunk from SCCs. However, thallium‐201 scintigraphy identified only the tumor and found no accumulation in other nodules. This finding suggests that thallium‐201 scintigraphy is useful for the diagnosis of SCC by excluding false‐positive signals detected by other imaging technologies.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The potential value of thallium‐201 scintigraphy in the diagnosis of squamous cell carcinoma arising from extensive pyoderma

Namiki

Makiguchi

Wada

et al. 2023

The Journal of Dermatology

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“…Considering that tuberculous granulomatous inflammation appears as 18 F-FDG avid lesions on PET/CT scans [27], this tool enables the delineation of disease extent and assessment of occult extra-pulmonary lesions in whole-body imaging [28]. Furthermore, 18 F-FDG PET/CT imaging is also effective in assessing treatment response during and after the therapy [28,29]. 18 F-FDG PET/CT imaging may be also useful in schistosomiasis, especially in the identification of infection sites: schistosomiasis is one of the most important parasitic infections in tropical and subtropical areas and represents a further cause of granulomatous disease, in which schistosome eggs trapped in organs lead to severe inflammatory reactions, including granulomas, appearing hypermetabolic on 18 F-FDG PET/CT [30].…”

Section: Pulmonary Granulomatosismentioning

confidence: 99%

PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals

Calabria,

Guadagnino,

Cimini

et al. 2024

Diagnostics

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Infectious diseases represent one of the most common causes of hospital admission worldwide. The diagnostic work-up requires a complex clinical approach, including laboratory data, CT and MRI, other imaging tools, and microbiologic cultures. PET/CT with 18F-FDG can support the clinical diagnosis, allowing visualization of increased glucose metabolism in activated macrophages and monocytes; this tracer presents limits in differentiating between aseptic inflammation and infection. Novel PET radiopharmaceuticals have been developed to overcome these limits; 11C/18F-labeled bacterial agents, several 68Ga-labeled molecules, and white blood cells labeled with 18F-FDG are emerging PET tracers under study, showing interesting preliminary results. The best choice among these tracers can be unclear. This overview aims to discuss the most common diagnostic applications of 18F-FDG PET/CT in infectious diseases and, as a counterpoint, to describe and debate the advantages and peculiarities of the latest PET radiopharmaceuticals in the field of infectious diseases, which will probably improve the diagnosis and prognostic stratification of patients with active infectious diseases.

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Nonmalignant Thoracic Disorders

Cited by 2 publications

References 64 publications

The potential value of thallium‐201 scintigraphy in the diagnosis of squamous cell carcinoma arising from extensive pyoderma

The potential value of thallium‐201 scintigraphy in the diagnosis of squamous cell carcinoma arising from extensive pyoderma

PET/CT Imaging of Infectious Diseases: Overview of Novel Radiopharmaceuticals

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