We investigate a class of multilayered metamaterials characterized by moderate-index inclusions and low average permittivity. Via first-principle calculations, we show that in such scenario first-and second-order spatial dispersion effects may exhibit a dramatic and non-resonant enhancement, and may become comparable to the local response. Their interplay gives access to a wealth of dispersion regimes encompassing additional extraordinary waves and topological phase transitions. In particular, we identify a novel configuration featuring bound and disconnected isofrequency contours. Since they do not rely on high-index inclusions, our proposed metamaterials may constitute an attractive and technologically viable platform for engineering nonlocal effects in the optical range.Metamaterials are artificial composites of dielectric and/or metallic inclusions in a host medium, which can be engineered so as to exhibit unconventional and/or tailored effective electromagnetic responses. As such, they constitute a unique platform for attaining novel optical mechanisms such as negative refraction, super-and hyper-lensing, invisibility cloaking, etc.[1]. In the long-wavelength limit, the metamaterial optical response is typically described in terms of macroscopic phenomenological parameters, such as effective permittivity and permeability [2]. However, if the inclusions are metallic and/or their size is not electrically small, nonlocal effects (i.e., spatial dispersion) may need to be accounted for, e.g., via the appearance of spatial derivatives of the fields in the effective constitutive relationships, or via wavevector-dependent constitutive parameters [31]. The reader is referred to [4][5][6][7][8] for a representative sampling of nonlocal homogenization approaches available in the topical literature. It is worth stressing that two cornerstones in metamaterial science, namely, artificial electromagnetic chirality and optical magnetism, are manifestations of firstand second-order spatial dispersion, respectively [9,10]. Artificial electromagnetic chirality (due to 3-D, 2-D and 1-D geometrical chirality [11]) yields interesting phenomena, such as giant optical activity, asymmetric transmission, and negative refractive index [12]. Artificial or optical magnetism may give rise to negative refractive index and backward-wave propagation [13].It is worth noting that second-order spatial dispersion is not fully equivalent to artificial magnetism [14], and this aspect has not been exploited to its fullest extent in applied science. Even though second-order and non-magnetic nonlocal effects are generally considered detrimental for several applications [15], they have been shown to support intriguing phenomena such as propagation of additional extraordinary waves [16,17] and topological transitions [14,18,19]. Within this context, harnessing these nonlocal effects currently represents one of the grand challenges of metamaterial science.Spatial dispersion is essentially ruled by the electrical size η = Λ/λ, with Λ denoting a charact...