Nonlinear regression model for the representation of dielectric constants for binary aprotic solvents

Synthesis of lovastatin with immobilizedCandida rugosa lipase in organic solvents: Effects of reaction conditions on initial rates

“…They are plotted in Figure 6 vs. the cosolvent volume fraction and the cosolvent mole fraction. Kolling (1985) has reported that ⑀ mix for binary Figure 5. Initial reaction rate of lovastatin synthesis plotted as a function of log P mix in cosolvent/hexane mixtures at 22°C, log P mix was calculated from Equation (1).…”

Kamlet-Taft .pi.* polarizability/dipolarity of mixtures of water with various organic solvents

“…To examine the dependence of * on the composition of mixtures and relate ir* to dielectric constant and refractive index, Kolling made use of what he terms the "excess" ir* (28). There is also a large body of data on the dielectric properties of hydroorganic mixtures (29)(30)(31)(32)(33).…”

Dielectric characterization of binary solvents containing acetonitrile

“…The static dielectric constant (e) remains a key descriptor of polarity in all solvent continuum models for medium effects upon electrolytic equilibria, ionic solvation and solubility, and ionic mechanisms of reaction. However, as one reviews the literature data on binary solvents, clearly the trend in <e with changing composition of the mixture is rarely an exact linear function for most cosolvent systems (6,7), and AN-cosolvent systems do not seem to be exceptions to that pattern (8)(9)(10)(11). On the other hand, the earlier dielectric constant data sets for acetonitrile-containing solvent pairs (8)(9)(10)(11) are typified by too restricted a mole fraction range for their mixtures and by being too limited in the types of cosolvents represented.…”

“…As a consequence, it is now possible to estimate the magnitude of the deviation from ideal dielectric behavior for the mixed solvent by applying a general linear regression in dipolarity and HBD acidity parameters for the added component. Likewise, nonlinear correlation functions of the form reported previously (6,7) were devised to represent the empirical trend in em vs. solvent composition for the ten more important cosolvent systems containing acetonitrile.…”

“…All other spectroscopic (ACS) grade solvents were redried and redistilled as reported previously (6), following standard procedures (12).…”