Nonlinear optical contrast enhancement for optical coherence tomography

Vinegoni, Claudio; Bredfeldt, Jeremy S.; Marks, Daniel L.; Boppart, Stephen A.

doi:10.1364/opex.12.000331

Cited by 85 publications

(66 citation statements)

References 23 publications

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“…OCT contrast enhancement (prerequisite 3) has been accomplished by introducing polarization-sensitive OCT, [24][25][26][27][28] phasesensitive OCT, [29][30][31][32][33] optical coherence elastography, [34][35][36][37][38][39] spectroscopic low coherence interferometry, [40][41][42][43] elastic scattering spectroscopy, 31,[44][45][46] and nonlinear interferometric vibrational imaging (NIVI), as well as employing endogenous or exogenous contrast. [47][48][49][50][51][52] In this paper, a recently developed contrast improvement for OCT, named label-free optical angiography, is reviewed (cf. Sec.…”

Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

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Abstract. In the last 25 years, optical coherence tomography (OCT) has advanced to be one of the most innovative and most successful translational optical imaging techniques, achieving substantial economic impact as well as clinical acceptance. This is largely owing to the resolution improvements by a factor of 10 to the submicron regime and to the imaging speed increase by more than half a million times to more than 5 million A-scans per second, with the latter one accomplished by the state-of-the-art swept source laser technologies that are reviewed in this article. In addition, parallelization of OCT detection, such as line-field and full-field OCT, has shortened the acquisition time even further by establishing quasi-akinetic scanning. Besides the technical improvements, several functional and contrast-enhancing OCT applications have been investigated, among which the label-free angiography shows great potential for future studies. Finally, various multimodal imaging modalities with OCT incorporated are reviewed, in that these multimodal implementations can synergistically compensate for the fundamental limitations of OCT when it is used alone. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Optical coherence tomography today: speed, contrast, and multimodality

Drexler¹,

Li²,

Kumar³

et al. 2014

J. Biomed. Opt

403

264

View full text Add to dashboard Cite

show abstract

“…At present, there are two reported MCOCT methods that fall within this category: second harmonic OCT (SH-OCT) (74)(75)(76) and CARS-based contrast OCT (named nonlinear interferometric vibrational imaging [NIVI] by its developers) (77). Both methods rely on using a molecular contrast agent within a target sample that can efficiently and coherently convert the incoming OCT probe light field into an emission that is detectable using interferometric approaches.…”

Section: Coherent Emission-based Mcoct Methodsmentioning

confidence: 99%

Molecular Contrast Optical Coherence Tomography: A Review

Yang¹

2004

Photochem Photobiol

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This article reviews the current state of research on the use of molecular contrast agents in optical coherence tomography (OCT) imaging techniques. After a brief discussion of the basic principle of OCT and the importance of incorporating molecular contrast agent usage into this imaging modality, we shall present an overview of the different molecular contrast OCT (MCOCT) methods that have been developed thus far. We will then discuss several important practical issues that define the possible range of contrast agent choice, the design criteria for engineered molecular contrast agent and the implementability of a given MCOCT method for clinical or biological applications. We will conclude by outlining a few areas of pursuit that deserve a greater degree of research and development.

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“…Specific contrast for different types of tissue or the chemical composition can also be gained by utilizing coherent non-linear effects in OCT [119]. Second harmonic generation (SHG), or frequency-doubling, does not occur in uniform, isotropic media and provides therefore specificity for anisotropic or birefringent structures, such as collagen layers [120,121].…”

Section: Molecular Contrastmentioning

confidence: 99%

Optical coherence tomography—current technology and applications in clinical and biomedical research

et al. 2011

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Optical coherence tomography (OCT) is a non-invasive imaging technique providing real-time twoand three-dimensional images of scattering samples with micrometer resolution. Mapping the local reflectivity, OCT visualizes the morphology of the sample. In addition, functional properties such as birefringence, motion or the distribution of certain substances can be detected with high spatial resolution. The main field of application is bio-medical imaging and diagnostics. In ophthalmology, OCT is accepted as a clinical standard for diagnosing and monitoring treatment of a number of retinal diseases, and OCT is becoming an important instrument for clinical cardiology. New applications are emerging in various medical fields, e. g. early-stage cancer detection, surgical guidance, and early diagnosis of musculoskeletal diseases. OCT has also proven its value as a tool for developmental biology. The number of companies involved in manufacturing OCT systems has increased substantially during the last years-especially due to its success in opthalmology-and this technology can be expected to continue to spread into various fields of application.

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Nonlinear optical contrast enhancement for optical coherence tomography

Cited by 85 publications

References 23 publications

Optical coherence tomography today: speed, contrast, and multimodality

Optical coherence tomography today: speed, contrast, and multimodality

Molecular Contrast Optical Coherence Tomography: A Review

Optical coherence tomography—current technology and applications in clinical and biomedical research

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