This paper considers active disturbance rejection control (ADRC) as a new control approach for pH neutralization process. The pH process is challenging to control due to its sensitivity to disturbance, nonlinear dynamics, and time-varying characteristics. Special attention is paid to the impact of disturbances typically exists in the chemical process. First, the pH neutralization process nonlinear model is presented, then the active disturbance rejection control is described briefly and a pH neutralization process closed-loop control system is designed on its bases, and investigated with simulation. More robust and better disturbance rejection performances are achieved compared to the control technique of feedback linearization (FL).