Nonlinear interdependence of the results of measuring anti-SARS-CoV-2 IgG levels using Abbott and Euroimmun test systems

Ivanov, A. V.; Kryshen, Evgeni; Семенова, Е. В.

doi:10.1016/j.jcv.2023.105448

Cited by 1 publication

(1 citation statement)

References 48 publications

(81 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our findings support Ivanov et al's conclusion that the anti-SARS-CoV-2 antibody levels assessed by the ABBOTT and Roche systems are not linear [45].…”

Section: Discussionsupporting

confidence: 91%

COVID-19 Antibody Seroconversion in Cancer Patients: Impact of Therapy Cessation—A Single-Center Study

Souan,

Abdel-Razeq,

Nashwan

et al. 2023

Vaccines

View full text Add to dashboard Cite

Background: The effective development of COVID-19 vaccination has mitigated its harm. Using two laboratory methods, we investigated the efficacy of the BNT162b2 mRNA and BBIBP-CorV COVID-19 vaccines on seroconversion rates in cancer patients undergoing active cancer treatment. Methods: SARS-CoV-2 vaccines were scheduled for 134 individuals. The consenting participants submitted three venous blood samples. Three samples: T0, T1, and T2. The ABBOTT-SARS-CoV-2 IgG II Quant and Elecsys® Anti-SARS-CoV-2 assays were used to evaluate the samples and convert the antibody titers to WHO (BAU)/mL units. Results: Cancer patients exhibited a higher seroconversion rate at T2, regardless of vaccination type, and the mean antibody titers at T1 and T2 were higher than those at T0. BBIBP-CorV patients required a booster because BNT162b2 showed a higher seroconversion rate between T0 and T1. Statistics indicate that comparing Abbott and Roche quantitative antibody results without considering the sample collection time is inaccurate. Conclusions: COVID-19 vaccines can still induce a humoral immune response in patients undergoing cancer-targeted therapy. The strength of this study is the long-term monitoring of antibody levels after vaccination in cancer patients on active therapy using two different immunoassays. Further multicenter studies with a larger number of patients are required to validate these findings.

show abstract

“…Our findings support Ivanov et al's conclusion that the anti-SARS-CoV-2 antibody levels assessed by the ABBOTT and Roche systems are not linear [45].…”

Section: Discussionsupporting

confidence: 91%