A new technique for manipulation and control of gradient-driven instabilities through nonlinear interaction with Alfvén waves in a laboratory plasma is presented. A narrow, field-aligned density depletion is created in the Large Plasma Device (LAPD), resulting in coherent, unstable fluctuations on the periphery of the depletion. Two independent shear Alfvén waves are launched along the depletion at separate frequencies, creating a nonlinear beat-wave response at or near the frequency of the original instability. When the beat-wave has sufficient amplitude, the original unstable mode is suppressed, leaving only the beat-wave response, generally at lower amplitude.PACS numbers: 52.35. Bj, 52.35.Mw, 52.35.Qz In magnetized plasmas in the laboratory, the loss of heat, particles, and momentum across the confining magnetic field is predominantly caused by turbulent transport associated with pressure-gradient-driven instabilities [1,2]. Controlling these instabilities to mitigate the transport they produce is therefore highly desirable for magnetic confinement fusion devices such as tokamaks. Direct control of gradient-driven instabilities has been achieved using arrays of electrodes or external saddle coils to induce fluctuating parallel currents in a cylindrical plasma device [3,4]. In these experiments, when the excited electric fields matched the frequency and wavenumber of a drift-wave mode in the device the observed turbulent spectrum collapsed onto the single coherent driven mode (synchronization) and turbulent transport is reduced [5]. Extending the transport control enabled through mode-synchronization to high-temperature fusion devices is highly desirable but it would not be possible using material electrodes. It is also not clear whether saddle coils would be effective at driving currents for synchronization in a high-performance device.Turbulence control with core plasma access might be achieved using externally-launched radiofrequency (RF) waves. High-power RF is expected to be an important tool for heating and current drive on next-step fusion experiments such as ITER [6] and could be available for application to turbulence and transport control. Creation of flow shear for turbulence suppression [7] using RF waves has been theorized [8] and recently demonstrated in the Alcator C-Mod tokamak [9,10]. Direct modification of gradient-driven instabilities is also possible through interaction with an RF field. Control of driftwave fluctuations was demonstrated in Q-machine experiments using lower hybrid waves to affect plasma properties and the drift-wave dispersion to suppress growth [11][12][13][14]. The modification of other transport related instabilities, such as the ion temperature gradient (ITG) instability, in the presence of RF driven fast magnetosonic waves has also been suggested and investigated theoretically [15]. This Letter reports on novel laboratory experiments using RF waves, in particular shear Alfvén waves (SAWs), to modify gradient-driven instabilities. Two copropagating SAWs with slightl...