In this article, the significance of chemical reaction and thermo-diffusion in Walters’ B fluid is examined with medium porosity under the influence of non-uniform heat generation\absorption. The nonlinear ordinary differential equations describing the flow are obtained via similarity variables and tackled by Homotopy Analysis Method. The results show among others that involvement of chemical reaction contributes to the shrinking of concentration buoyancy effect while dimensionless temperature overshoot with large values of convective heat parameter and heat generation\absorption which enable thermal potency to gain entrance to the quiescent-fluid, indicating that the two parameters can be used for drying of the components.