Nonlinear fluorescence response driven by ATP-induced self-assembly of guanidinium-tethered tetraphenylethene

Noguchi, Takao; Shiraki, Tomohiro; Dawn, Arnab; Tsuchiya, Youichi; Lien, Le Thi Ngoc; Yamamoto, Tatsuhiro; Shinkai, Seiji

doi:10.1039/c2cc33262k

Cited by 91 publications

(50 citation statements)

References 22 publications

(13 reference statements)

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“…The assay can also be carried out in diluted serum with a linear working range up to 175 U L −1 , suggesting its potential applications in clinical analyses of ALP levels in real samples. AIEgens have also been utilized to develop bioprobes working in a fluorescence turn‐on or light‐up mode for the detection of ATP, analysis of lectin–oligosaccharide interaction, examination of histone deacetylase activity, sensing of cholera toxin, testing of biogenic amines, real‐time monitoring of cell apoptosis, visualization of intracellular location and DNA origami, and assaying of other biological species …”

Section: Exploration Of High‐tech Applicationsmentioning

confidence: 99%

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

et al. 2014

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"United we stand, divided we fall."--Aesop. Aggregation-induced emission (AIE) refers to a photophysical phenomenon shown by a group of luminogenic materials that are non-emissive when they are dissolved in good solvents as molecules but become highly luminescent when they are clustered in poor solvents or solid state as aggregates. In this Review we summarize the recent progresses made in the area of AIE research. We conduct mechanistic analyses of the AIE processes, unify the restriction of intramolecular motions (RIM) as the main cause for the AIE effects, and derive RIM-based molecular engineering strategies for the design of new AIE luminogens (AIEgens). Typical examples of the newly developed AIEgens and their high-tech applications as optoelectronic materials, chemical sensors and biomedical probes are presented and discussed.

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Section: Exploration Of High‐tech Applicationsmentioning

confidence: 99%

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

et al. 2014

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“…Similar to the other guanidinium‐tethered TPE sensors, a sigmoidal curve was observed at the beginning of the titration process for both G1 and G2 , with the addition of low concentrations of ATP (Figure ) . The non‐linear relationship for ATP recognition provided an opportunity for a high signal‐to‐background ratio, leading to higher detection sensitivity . The G2 –ATP aggregation arising from electrostatic interactions was further confirmed by dynamic light scattering (DLS) measurements and scanning electron microscopy (SEM).…”

Section: Resultsmentioning

confidence: 99%

Dynameric Frameworks with Aggregation‐Induced Emission for Selective Detection of Adenosine Triphosphate

Zhang

et al. 2018

ChemPlusChem

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Luminogenic materials with aggregation‐induced emission (AIE) have attracted considerable interest for applications. If these systems aggregate, the free rotation of their scaffold is restricted, and as a consequence the photoluminescence increases. Herein, the first experimental observation of a “dynameric effect” on AIE is described. A comparison is made of the AIE of molecular and dynameric sensors that exhibit non‐linear turn‐on switching of fluorescence upon their interaction with adenosine triphosphate (ATP). Confirmation was obtained from the enhanced ATP detection with multivalent dynameric networks compared with a molecular sensor. The dynamic, reversible behaviour of the imine linkages is critical to produce this enhancement, as a static, imine‐reduced, polymeric sensor showed decreased AIE activity. The dynameric frameworks showed selectivity for ATP over adenosine diphosphate, and adenosine monophosphate over guanosine triphosphate or cytidine triphosphate. Together, these results will accelerate the systematic discovery of efficient adaptive biomimetic sensors.

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“…[77][78][79][80][81] We also designed several molecular sensing systems utilizing the spectral changes induced by molecular assembling phenomena. [65,[82][83][84][85][86][87] In the present system, we have found that complexation of PT-1 with lithocholate induces the dramatic spectral changes, particularly in its fluorescence spectra. We therefore considered that this system would be also applicable for molecular sensing.…”

Section: Applications Of Pt-1/lithocholate Complex For Molecular Recomentioning

confidence: 99%

Conformation Control of a Conjugated Polymer through Complexation with Bile Acids Generates Its Novel Spectral and Morphological Properties

Tsuchiya

Noguchi²,

Yoshihara

et al. 2016

Langmuir

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Control of higher-order polymer structures attracts a great deal of interest for many researchers when they lead to the development of materials having various advanced functions. Among them, conjugated polymers that are useful as starting materials in the design of molecular wires are particularly attractive. However, an equilibrium existing between isolated chains and bundled aggregates is inevitable and has made their physical properties very complicated. As an attempt to simplify this situation, we previously reported that a polymer chain of a water-soluble polythiophene could be isolated through complexation with a helix-forming polysaccharide. More recently, a covalently self-threading polythiophene was reported, the main chain of which was physically protected from self-folding and chain-chain π-stacking. In this report, we wish to report a new strategy to isolate a water-soluble polythiophene and to control its higher-order structure by a supramolecular approach: that is, among a few bile acids, lithocholate can form stoichiometric complexes with cationic polythiophene to isolate the polymer chain, and the higher-order structure is changeable by the molar ratio. The optical and morphological studies have been thoroughly performed, and the resultant complex has been applied to the selective recognition of two AMP structural isomers.

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Nonlinear fluorescence response driven by ATP-induced self-assembly of guanidinium-tethered tetraphenylethene

Abstract: Nonlinear fluorescence response, which is particularly important to attain the high signal-to-background ratio, was realized by the aggregation-induced fluorescence increase of guanidinium-tethered tetraphenylethene with ATP.

Cited by 91 publications

References 22 publications

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

Aggregation‐Induced Emission: The Whole Is More Brilliant than the Parts

Dynameric Frameworks with Aggregation‐Induced Emission for Selective Detection of Adenosine Triphosphate

Conformation Control of a Conjugated Polymer through Complexation with Bile Acids Generates Its Novel Spectral and Morphological Properties

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