Nonlinear dynamics of acoustic bubbles excited by their pressure-dependent subharmonic resonance frequency: influence of the pressure amplitude, frequency, encapsulation and multiple bubble interactions on oversaturation and enhancement of the subharmonic signal

Sojahrood, Amin Jafari; Earl, R.; Haghi, Hossein; Li, Q.; Porter, Tyrone M.; Kolios, Michael C.; Karshafian, Raffi

doi:10.1007/s11071-020-06163-8

Cited by 53 publications

(64 citation statements)

References 97 publications

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“…The acoustic pressure p a = − p A sin(2πft), where p A and f are the ultrasound amplitude and frequency, respectively. Note that the time delay while the pressure radiated by one bubble propagating to the other bubble was neglected in Eq (1) , it is reasonable because the initial bubble−bubble distances are small (d 0 < 100 μm) in this study, in which case the time delays become insignificant [36] , [43] . Sojahrood et al have provided a nice review of the time delays in the interacting bubble simulations [43] .…”

Section: Theory and Methodsmentioning

confidence: 99%

“…Note that the time delay while the pressure radiated by one bubble propagating to the other bubble was neglected in Eq (1) , it is reasonable because the initial bubble−bubble distances are small (d 0 < 100 μm) in this study, in which case the time delays become insignificant [36] , [43] . Sojahrood et al have provided a nice review of the time delays in the interacting bubble simulations [43] . Moreover, taking the time delay into account would make the numerical simulations more complex and computationally intensive, especially for the time-varying bubble−bubble distance while the translational motions of bubbles were simultaneously considered in this study.…”

Section: Theory and Methodsmentioning

confidence: 99%

Section: Theory and Methodsmentioning

confidence: 99%

“…As a powerful and valuable tool to analyze the nonlinear characteristics of one system, the bifurcation analysis has been extensively used to investigate the nonlinear dynamics of the interacting bubbles [43] , [45] , [46] , [47] , [48] , [49] . It has demonstrated that the qualitative and quantitative changes of the nonlinear dynamics could be investigated effectively over a wide range of control parameters [43] , [45] , [46] , [47] , [48] , [49] . However, the conventional bifurcation analysis may be misleading and cannot reliably identify features that are responsible for the identification of super-harmonic and ultra-harmonic oscillations [43] , [50] , [51] , [52] , [53] .…”

Section: Theory and Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Nonlinear dynamics and acoustic emissions of interacting cavitation bubbles in viscoelastic tissues

Qin

Zou

Lei

et al. 2021

Ultrasonics Sonochemistry

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Highlights The radial and translational motions of two interacting bubbles are studied. Bubble dynamics is analyzed by bifurcation structures and acoustic emission spectra. Small bubble is remarkably suppressed, while large bubble is slightly enlarged. Bubble−bubble interaction reduces the nonlinear dynamics and acoustic emissions. Viscoelasticity of the medium reduces the radial and translational bubble motions.

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Section: Theory and Methodsmentioning

confidence: 99%

Section: Theory and Methodsmentioning

confidence: 99%

Section: Theory and Methodsmentioning

confidence: 99%

Section: Theory and Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Nonlinear dynamics and acoustic emissions of interacting cavitation bubbles in viscoelastic tissues

Qin

Zou

Lei

et al. 2021

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

show abstract

“…(12) , while the red dots in panel B correspond to the lowest required equivalent pressure amplitude

to reach relative expansion

[75] , [66] . This threshold correlates with the minimum threshold of bubble destruction of

[111] The frequencies

and pressure amplitudes

corresponding to the optimal setup are denoted by green and blue colours, respectively. In panel C, the growth rate values obtained at the optimal parameter set are plotted as the function of the bubble size.…”

Section: Numerical Resultsmentioning

confidence: 95%

GPU accelerated numerical investigation of the spherical stability of an acoustic cavitation bubble excited by dual-frequency

Klapcsik

2021

Ultrasonics Sonochemistry

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The spherical stability of an acoustic cavitation bubble under dual-frequency excitation is investigated numerically. The radial dynamics is described by the Keller–Miksis equation, which is a second-order ordinary differential equation. The surface dynamics is modelled by a set of linear ordinary differential equation according to Hao and Prosperetti (1999), which takes into account the effect of vorticity by boundary layer approximation. Due to the large amount of investigated parameter combinations, the numerical computations were carried out on graphics processing units. The results showed that for bubble size between and , the combination of a low and a high frequency, and the combination of two close but not equal frequencies are important to prevent the bubble losing its shape stability, while reaching the chemical threshold ( ) (Kalmár et al., 2020). The phase shift between harmonic components of dual-frequency excitation has no effect on the shape stability.

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Extrusion: A New Method for Rapid Formulation of High‐Yield, Monodisperse Nanobubbles

Counil

Abenojar

Perera

et al. 2022

Small

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Shell‐stabilized gas microbubbles (MB) and nanobubbles (NB) are frequently used for biomedical ultrasound imaging and therapeutic applications. While it is widely recognized that monodisperse bubbles can be more effective in these applications, the efficient formulation of uniform bubbles at high concentrations is difficult to achieve. Here, it is demonstrated that a standard mini‐extruder setup, commonly used to make vesicles or liposomes, can be used to quickly and efficiently generate monodisperse NBs with high yield. In this highly reproducible technique, the NBs obtained have an average diameter of 0.16 ± 0.05 µm and concentration of 6.2 ± 1.8 × 1010 NBs mL−1 compared to 0.32 ± 0.1 µm and 3.2 ± 0.7 × 1011 mL−1 for NBs made using mechanical agitation. Parameters affecting the extrusion and NB generation process including the temperature, concentration of the lipid solution, and the number of passages through the extruder are also examined. Moreover, it is demonstrated that extruded NBs show a strong acoustic response in vitro and a strong and persistent US signal enhancement under nonlinear contrast enhanced ultrasound imaging in mice. The extrusion process is a new, efficient, and scalable technique that can be used to easily produce high yield smaller monodispersed nanobubbles.

show abstract

Nonlinear dynamics of acoustic bubbles excited by their pressure-dependent subharmonic resonance frequency: influence of the pressure amplitude, frequency, encapsulation and multiple bubble interactions on oversaturation and enhancement of the subharmonic signal

Cited by 53 publications

References 97 publications

Nonlinear dynamics and acoustic emissions of interacting cavitation bubbles in viscoelastic tissues

Nonlinear dynamics and acoustic emissions of interacting cavitation bubbles in viscoelastic tissues

GPU accelerated numerical investigation of the spherical stability of an acoustic cavitation bubble excited by dual-frequency

Extrusion: A New Method for Rapid Formulation of High‐Yield, Monodisperse Nanobubbles

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