The architectural heritage of masonry constructions, widely spread in the Italian country, is extremely vulnerable when compared to the high level of seismicity of the peninsula. Most of this heritage is nowadays still characterized by unreinforced historical masonry which due to deterioration phenomena caused by ageing, the changing of use conditions, the dated construction and design criteria, is already showing active damage processes. These conditions of decay and vulnerability, under earthquake can lead to major collapse scenarios. A reliable modeling of masonry material response becomes essential to understand and prevent such damage phenomena in the structures. To achieve this purpose there is a need to adopt constitutive laws accounting for damage, plasticity and other main phenomena, thus to be able to capture the strain softening behavior of masonry material in seismic conditions. Relying on these grounds, the following paper presents the study conducted on an arch bridge, located in Italy, built with a traditional stone masonry. Through modal analysis, pushover and time history analysis campaign, the structural response of the structure is investigated. The 3D modeling of the structure is carried out by means of the finite element software FEAP, characterizing masonry through the constitutive damage law Addessi and Sacco 2016, within a macromechanical modeling. In addition to monitoring the most usual engineering demand parameters (EDPs), the implemented procedure allows to follow the evolution of decay by means of damage maps and damage indexes, useful tools for an accurate insight into the vulnerabilities of the bridge when subjected to horizontal actions.