project, funded by EU in the context of 6th Framework Program. It enables the creation of efficient low-order, medium fidelity models particularly suitable for structural sizing, aeroelastic analysis and optimization at the conceptual design level. The whole methodology is based upon the integration of geometry construction, aerodynamic and structural analysis codes that combine depictive, computational, analytical, and semi-empirical methods, validated in an aircraft design environment. The result is a design tool based on computational methods for the aero-structural analysis and multi disciplinary optimization (MDO) of aircraft layouts at the conceptual design stage. A complete case study regarding the TransoniCRuiser aircraft, including validation results obtained using industrial standard tools like MSC/NASTRAN and medium fidelity CFD codes like Edge, is also reported.