Nonlinear Dependence of Fish Bioconcentration on <i>n</i>-Octanol/Water Partition Coefficient

Bintein, S.; Devillers, James; Karcher, W.

doi:10.1080/10629369308028814

Cited by 121 publications

(88 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Connell and Hawker (58) reanalyzed published bioconcentration data for fish and proposed a fourth-order polynomial relationship with a maximum wet weight log BCF value of 4.6 for compounds with a log Kow value of 6.7. Related parabolic (second order) and bilinear relationships have been proposed by Bintein et al (59). The apparent BCFs determined for Asellus are in agreement with these curvilinear relationships.…”

Section: Bcf In Relation To Kow the Bcfs Observed For Pahs In A Aqusupporting

confidence: 78%

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Hattum¹,

Montañés²

1999

Environ. Sci. Technol.

View full text Add to dashboard Cite

A novel method based on a first-order two-compartment model was used to determine the bioconcentration and toxicokinetic rate constants of six different polycyclic aromatic hydrocarbons (PAHs) in the freshwater isopod Asellus aquaticus, a common species in most European freshwater systems. Numerical integration and iterative parameter estimation techniques were applied to account for time-varying aqueous exposure concentrations. All PAHs exhibited a rapid uptake. Monophasic elimination patterns were observed for benzo[e]pyrene and benzo[a]pyrene (biological half-life t 0.5 : 7-8 days). For the other PAHs (anthracene, phenanthrene, pyrene, benzo[ghi]perylene) typical biphasic patterns were encountered with rapidly (t 0.5 : 0.6-2 days) and slowly (t 0.5 : 99to>1000 days) exchanging compartments. Some PAHs (pyrene and benzo[ghi]perylene) will hardly be eliminated during the normal life span of the organism. Bioconcentration factors (log BCF, wet weight; derived from rate constants) increased with molecular weight and K ow (n-octanol/water partition coefficient) from 2.6 L kg -1 (anthracene) to 5.7 L kg -1 (benzo-[ghi]perylene). A linear relationship was observed between log BCF and log K ow. It is argued that biotransformation of PAHs in freshwater isopods seems to play a minor role and that this species may be suitable for the assessment of the bioavailability of PAHs in littoral freshwater environments.

show abstract

Section: Bcf In Relation To Kow the Bcfs Observed For Pahs In A Aqusupporting

confidence: 78%

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Hattum¹,

Montañés²

1999

Environ. Sci. Technol.

View full text Add to dashboard Cite

show abstract

“…Equation 19 gives such a drop, where the bioconcentration reaches a maximum and then falls above log K ow of 6. Devillers et al (1998) found that the Bintein et al (1993) gives good simulation results and that the model presents a large log K ow domain of application.…”

Section: Empirical Bcf Modelsmentioning

confidence: 98%

“…USEPA (1995aUSEPA ( , 1995c. Devillers et al (1996) studied several published correlations for bioconcentration factor and recommended the equation reported by Bintein et al (1993). This model relates BCF fish (L/kg fish tissue) to K ow , log 0.91× log -1.975 log (6.8 -7 × + 1) -0.786…”

Section: Bioaccumulation In Fishmentioning

confidence: 99%

“…Mackay (1982) also examined the same data and argued that the slope of 0.85 was not significantly different from 1.0 and that the simpler one-parameter relationship applies. Many of the empirical relationships tend to break down when dealing with highly hydrophobic chemicals (Bintein et al 1993). …”

Section: Empirical Bcf Modelsmentioning

confidence: 99%

“…Meylan et al (1999) analyzed and grouped 694 chemicals and obtained several correlations for nonionic and ionic compounds, including correction factors for the BCF estimation of several compound classes. For both groups of compounds, the proposed equations resulted in a higher correlation coefficient than for equations established with other empirical models, such as Veith et al (1979) and Bintein et al (1993). The equations of Meylan have the advantages that they are based on a large data set with a wide range of K ow , they allow for metabolic conversion, and they can be used for ionic compounds.…”

Section: Empirical Bcf Modelsmentioning

confidence: 99%

See 2 more Smart Citations

Data Gap Analysis and Database Expansion of Parameters for Munitions Constituents

Dortch¹,

Zakikhani²,

Furey³

et al. 2005

View full text Add to dashboard Cite

Training and munitions firing activities at military ranges are operations vital to the readiness of the U.S. Army. These activities involve the use of pyrotechnic, explosive, and incendiary compounds. During an initial effort, the U.S. Army Engineer Research and Development Center (ERDC) and the U.S. Army Center for Health Promotion and Preventive Medicine (CHPPM) developed a Range Database for 188 chemicals of range interest specified by the U.S. Army Environmental Center. Significant gaps existed in the initial database, which included 11 priority physicochemical properties and human toxicological benchmarks. In recognition of the substantial remaining data gaps in the Range Database, this study was conducted by ERDC and CHPPM to expand the database for additional properties and human exposure parameters and to fill data gaps to the extent possible, even to include computational or estimation methods, if appropriate. The study effort was divided into five property/parameter categories: physicochemical properties for fate and transport, human exposure parameters, food transfer factors, environmental degradation rates and half-lives, and human toxicological benchmarks. The accuracy of estimation methods was evaluated. Recommendations are made for estimation methods and future research to address any remaining data gaps or to improve estimates. The data are being added to a relational database.

show abstract

Environmental Chemistry: QSAR

Devillers¹

1998

Encyclopedia of Computational Chemistry

View full text Add to dashboard Cite

Nonlinear Dependence of Fish Bioconcentration on n-Octanol/Water Partition Coefficient

Cited by 121 publications

References 23 publications

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Toxicokinetics and Bioconcentration of Polycyclic Aromatic Hydrocarbons in Freshwater Isopods

Data Gap Analysis and Database Expansion of Parameters for Munitions Constituents

Environmental Chemistry: QSAR

Contact Info

Product

Resources

About