Nonlinear changes in the activity of the oxygen-dependent demethylase system in Rhodococcus erythropolis cells in the presence of low and very low doses of formaldehyde

Malarczyk, Elżbieta; Paździoch-Czochra, Marzanna; Grąz, Marcin; Kochmańska-Rdest, Janina; Jarosz-Wilkołazka, Anna

doi:10.1186/1753-4631-5-9

Cited by 20 publications

(27 citation statements)

References 34 publications

(42 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Section: Salient Signal For the Systemsupporting

confidence: 73%

“…The graphs show a sinusoidal response dependent upon the different noise levels [136] and a peak value at a specific noise level [135]. Such sinusoidal doseresponse phenomena are similar to the sinusoidal dose-response curves noted for homeopathically-prepared medicines in a bacterial cell metabolism model [126].In statistical physics, Joshi has also shown that weak coupling in a double quantum dot system can exhibit stochastic resonance [138]. A substantial proportion of NPs in at least some homeopathic medicines fall into the quantum dot size range of 1-10 nanometers in diameter [3].…”

supporting

confidence: 72%

Section: Salient Signal For the Systemmentioning

confidence: 99%

“…Other studies have demonstrated that low doses of homeopathically-prepared metals, including cadmium and arsenic, can produce beneficial hormetic reversal of effects of higher, toxic doses of the same or crosssensitized agent on heat shock protein activation patterns [124]. Heat shock proteins are among the biological modulators of the stress response networks involved in adaptation to various environmental stressors [94,125].In the homeopathic NP dose range, the low dose hormetic effects can take on the sinusoidal oscillatory dose-response patterns reported in various preclinical and clinical studies [5,73,126]. To avoid toxicity but still elicit the adaptive response of hormesis with nanoforms of some agents such as poisonous plants, that are otherwise toxic at higher doses, extremely low doses, i.e., picogram/milliliter to low nanogram levels, may be necessary [21].…”

mentioning

confidence: 99%

“…In parallel, it may require a more salient match between the signal quality of the small medicine dose and the endogenous emergent "noise" of the disease dysfunctions occurring within the system to evoke stochastic resonance. At higher potency medicines, SR could account for the hormesis-like phenomena observed and explain in part why the doseresponse curve is sinusoidal in nature [126].On the other hand, simple nanoparticle-based biological amplification of beneficial herbal or mineral salt effects may be more relevant than SR at very low potencies (triturated and/or minimally diluted and succussed nanoparticles). In this scenario, repeated doses might lead to time-dependent sensitization.…”

mentioning

confidence: 99%

See 4 more Smart Citations

Nonlinear Response Amplification Mechanisms for Low Doses of Natural Product Nanomedicines: Dynamical Interactions with the Recipient Complex Adaptive System

Bell

Sarter

Koithan

et al. 2013

J Nanomed Nanotechol

View full text Add to dashboard Cite

The purpose of the present paper is (a) to outline the self-organized, complex adaptive network nature of the organism as recipient of nanomedicines; (b) to propose several nonlinear endogenous amplification processes by which pulsed low doses of traditional, homeopathically-manufactured natural product nanomedicines may stimulate a return toward healthier function; and (c) to discuss their potential relevance to novel, but safer than conventional dosing strategies for contemporary nanomedicines. Homeopathy is an over 200-year-old system of complementary and alternative medicine (CAM) that uses low doses of natural plant-, mineral-, and animal-sourced nanomedicines. Homeopathic manufacturing is "green", with mechanical grinding in lactose and agitation in ethanol-water as primary reagents. Agitation within glass containers at room temperature may also contribute nanosilica and nanosilicon as drug delivery vehicles and biological amplifiers. The medicine selection is matched to the recipient organism's systemic patterns of dysfunction and pulsed in the timing of the discrete doses. Endogenous amplification processes within the recipient organism may involve hormesis, time-dependent sensitization, and/or stochastic resonance. Effects are adaptive and systemically diffuse, i.e., causally indirect, rather than pharmacological and local, i.e., direct. All of these nonlinear response processes require interaction of the nanoparticle (NP) dose with the organism as a complex adaptive system. The pulsed NP dose serves as a low intensity salient danger signal for the organism to make network-wide adaptive changes that can lead to healing. The historically safe therapeutic approach of homeopathic nanomedicine dosing avoids risks of high, continuous doses and cumulative toxicity that contemporary nanomedicine researchers are now trying to solve while using NPs as if they were conventional bulk drugs. Integrating the insights, technical procedures, and clinical dosing approaches from modern and homeopathic nanomedicine could lead to major advances in the field for more effective and safer translational applications.NPs in homeopathic medicines [3]. NP concentrations are low, but measurable [3]. Like modern manufactured NPs [13], homeopathicallymanufactured medicines in solution also can exhibit aging effects [9,14]. These nanomedicines are delivered either in ethanolic liquids or sprayed and dried onto lactose or lactose/sucrose pellets for oral administration.Homeopathic manufacturing materials and methods are inherently "green" [15,16]. Previous papers have addressed the striking similarities between modern top-down mechanical attrition procedures for making nanoparticles (NPs) [17] and historical homeopathic medicine manufacturing methods and materials [15,[18][19][20][21]. These similarities include mechanically grinding source materials in lactose for hours and repeatedly agitating ethanol-water solutions containing the source Citation: Bell IR, Sarter B, Koithan M, Standish LJ, Banerji P, et al. (2013) Nonlinea...

show abstract

Section: Salient Signal For the Systemsupporting

confidence: 73%