Hybrid normal metal -insulator -superconductor microstructures suitable for studying an interference of electrons were fabricated. The structures consist of a superconducting loop connected to a normal metal electrode through a tunnel barrier . An optical interferometer with a beam splitter can be considered as a classical analogue for this system. All measurements were performed at temperatures well below 1 K. The interference can be observed as periodic oscillations of the tunnel current (voltage) through the junction at fixed bias voltage (current) as a function of a perpendicular magnetic field. The magnitude of the oscillations depends on the bias point. It reaches a maximum at energy eV which is close to the superconducting gap and decreases with an increase of temperature. Surprisingly, the period of the oscillations in units of magnetic flux ∆Φ is equal neither to h/e nor to h/2e, but significantly exceeds these values for larger loop circumferences. The origin of the phenomena is not clear.