Nonlinear Acoustics and Imaging

Szabo, Thomas L.

doi:10.1016/b978-0-12-396487-8.00012-4

Cited by 13 publications

(7 citation statements)

References 132 publications

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“…Uniform tissue was used for the remaining distances. The parameters α0 = 0.00220 dB/(cm MHz) [31], b = 2, c = 1482.3 m/s, density ρ = 1000 kg/m 3 , and B/A = 4.96 [33] were used for the simulation of the propagation in water. Although the experimental work was conducted in prostate adenocarcinoma, parameters for human prostate tissue were used in the simulations.…”

Section: Simulation Of Arfmentioning

confidence: 99%

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Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors

Afadzi

Myhre

Yemane

et al. 2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Acoustic radiation force (ARF) might improve the distribution of nanoparticles (NPs) in tumors. To study this, tumors growing subcutaneously in mice were exposed to focused ultrasound (FUS) either 15 min or 4 h after the injection of NPs, to investigate the effect of ARF on the transport of NPs across the vessel wall and through the extracellular matrix. Quantitative analysis of confocal microscopy images from frozen tumor sections was performed to estimate the displacement of NPs from blood vessels. Using the same experimental exposure parameters, ARF was simulated and compared to the experimental data. Enhanced interstitial transport of NPs in tumor tissues were observed when FUS (10 MHz, acoustic power 234 W/cm 2 , 3.3 % duty cycle) was given either 15 min or 4 h after NP administration. According to acoustic simulations, the FUS generated an ARF per unit volume of 2.0 x 10 6 N/m 3 . The displacement of NPs was larger when FUS was applied 4h after NP injection compared to after 15 min. This study shows that ARF might contribute to a modest improved distribution of NPs into the tumor interstitium.

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Section: Simulation Of Arfmentioning

confidence: 99%

“…With b=1.3 and f=5 MHz, (2) yields α0=0.48 dB/(cm MHz 1.3 ), which was used in the simulations. The other parameters were c = 1561 m/s [34], ρ = 1045 kg/m 3 [35] and B/A = 7.43 (B/A of muscle [33]).…”

Section: Simulation Of Arfmentioning

confidence: 99%

Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors

Afadzi

Myhre

Yemane

et al. 2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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“…The parameters for water were: 𝛼 = 0. 025 Np/m [31], 𝑏 = 2, 𝑐 = 1482 m/s, density 𝜌 = 1000 kg/m 3 , and nonlinearity parameter (B/A) = 4.96 [33] and for collagen gel: 𝛼 = 0.18 Np/m [34], 𝑏 = 1.6 [34], c = 1496 m/s [35], 𝜌 = 1116 kg/m 3 [35] and B/A = 7.43 (B/A of muscle [33] due to lack of experimental data for collagen gel). The surface transducer pressures used as input parameters in simulation of the ARF were determined as described in Appendix A, and found to be 105, 146 and 206 kPa for peak negative pressures of 2.2, 2.7 and 3.0 MPa.…”

Section: ) Arf Estimationmentioning

confidence: 99%

Effect of Acoustic Radiation Force on Displacement of Nanoparticles in Collagen Gels

Løvmo

Yemane

Bjørkøy

et al. 2021

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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Penetration of nanoscale therapeutic agents into the extracellular matrix (ECM) of a tumor is a limiting factor for sufficient delivery of drugs in tumors. Ultrasound in combination with microbubbles causing cavitation, is reported to improve delivery of nanoparticles (NPs) and drugs to tumors. Acoustic radiation force (ARF) could also enhance the penetration of NPs in tumor ECM. In this work, a collagen gel was used a model for tumor ECM to study the effect of ARF on the penetration of NPs as well as deformation of collagen gels applying different ultrasound (US) parameters (varying pressure and duty cycle). The collagen gel was characterized, and diffusion of water and diffusion of NPs measured. The penetration of NPs into the gel and was measured by confocal laser scanning microscopy and numerical simulations was performed to determine the ARF and to estimate penetration distance and extent of deformation. ARF had no effect on the penetration of NPs into the collagen gels for the US parameters and gel used, whereas a substantial deformation was observed. The width of the deformation on the collagen gel surface corresponded to the US beam. Comparing ARF caused by attenuation within the gel and Langevin pressure caused by reflection at the gel-water surface, ARF was the dominant mechanism for the gel deformation. The experimental and theoretical results were consistent both with respect to NP penetration and gel deformation.

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“…Echolocation is the use of reflected sound to locate and identify objects, particularly used by animals like dolphins and bats. According to [Szabo 2014], bats emit ultrasound pulses, ranging between 20-150 kHz, to catch an insect prey with a resolution of 2-15 mm. This involves signal processing such as:…”

Section: Echolocationmentioning

confidence: 99%

“…PW is preferred for theoretical and empirical reasons. First, the transmission frequency 𝑓 0 may experience considerable downshift as a result of absorption and diffraction effects [Szabo 2014]. Therefore, using pulsed waves independent for each emission is theoretically better than continuous waves compared to 𝑓 0 .…”

Section: Sound Sourcementioning

confidence: 99%

Echo-Reconstruction: Audio-Augmented 3D Scene Reconstruction

Wilson,

Rewkowski,

Lin

et al. 2021

Preprint

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Nonlinear Acoustics and Imaging

Cited by 13 publications

References 132 publications

Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors

Effect of Acoustic Radiation Force on the Distribution of Nanoparticles in Solid Tumors

Effect of Acoustic Radiation Force on Displacement of Nanoparticles in Collagen Gels

Echo-Reconstruction: Audio-Augmented 3D Scene Reconstruction

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