Nonfactorizable contributions to exclusive two-body nonleptonic weak decays of heavy mesons arising from color octet currents, characterized by the parameter r 2 , are extracted from the data. It is found that r 2 is equal to ∼ −0.67 , −(0.9 ∼ 1.1), − (1.2 ∼ 1.3), ∼ 0.36 respectively for D →Kπ,K * π,K * ρ,B → Dπ decays. As expected, soft-gluon effects become stronger when the decay particles are less energetic, allowing more time for significant final-state strong interactions. As a consequence, the parameter a 2 is not universal and is channel or class dependent, contrary to the anticipation of the factorization approach.The leading 1/N c expansion works most successfully for D →Kπ decays as the subleading 1/N c factorizable contribution is almost compensated by the soft-gluon effect. We argue that,in contrast to what happens in B − → D ( * ) π(ρ) decays, the nonfactorizable term and the subleading 1/N c factorizable term inB → ψK ( * ) decays are opposite in signs, in accordance with a recent QCD sum rule calculation. Implications are discussed.