Noniterative method of reconstruction optical coherence tomography images with improved lateral resolution in semitransparent media

Moiseev, Alexander A.; Gelikonov, Grigory V.; Терпелов, Д. А.; Shilyagin, Pavel A.; Gelikonov, V. M.

doi:10.1088/1612-2011/10/12/125601

Cited by 18 publications

(12 citation statements)

References 31 publications

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“…The study was performed with a spectral-domain OCT device with the CP detection method developed in the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod, Russia) 42,43 . The utilized device has a common-path interferometric layout that operates at a 1.3 µm central wavelength with axial and lateral resolutions of 10 µm and 15 µm in air, respectively.…”

Section: Methodsmentioning

confidence: 99%

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Yashin

Kiseleva

Moiseev

et al. 2019

Sci Rep

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Optical coherence tomography (OCT) is a promising method for detecting cancer margins during tumor resection. This study focused on differentiating tumorous from nontumorous tissues in human brain tissues using cross-polarization OCT (CP OCT). The study was performed on fresh ex vivo human brain tissues from 30 patients with high- and low-grade gliomas. Different tissue types that neurosurgeons should clearly distinguish during surgery, such as the cortex, white matter, necrosis and tumorous tissue, were separately analyzed. Based on volumetric CP OCT data, tumorous and normal brain tissue were differentiated using two optical coefficients — attenuation and forward cross-scattering. Compared with white matter, tumorous tissue without necrotic areas had significantly lower optical attenuation and forward cross-scattering values. The presence of particular morphological patterns, such as necrosis and injured myelinated fibers, can lead to dramatic changes in coefficient values and create some difficulties in differentiating between tissues. Color-coded CP OCT maps based on optical coefficients provided a visual assessment of the tissue. This study demonstrated the high translational potential of CP OCT in differentiating tumorous tissue from white matter. The clinical use of CP OCT during surgery in patients with gliomas could increase the extent of tumor resection and improve overall and progression-free survival.

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Section: Methodsmentioning

confidence: 99%

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Yashin

Kiseleva

Moiseev

et al. 2019

Sci Rep

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show abstract

“…The ex vivo studies were performed with an multimodal OCT device with cross-polarization detection developed by the Institute of Applied Physics of the Russian Academy of Sciences (Nizhny Novgorod, Russia) (21, 22). The device operates at a central wavelength of 1.3 μm providing axial and lateral resolutions, in air, of 10 and 15 μm, respectively.…”

Section: Methodsmentioning

confidence: 99%

Cross-Polarization Optical Coherence Tomography for Brain Tumor Imaging

et al. 2019

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This paper considers valuable visual assessment criteria for distinguishing between tumorous and non-tumorous tissues, intraoperatively, using cross-polarization OCT (CP OCT)—OCT with a functional extension, that enables detection of the polarization properties of the tissues in addition to their conventional light scattering. Materials and Methods: The study was performed on 176 ex vivo human specimens obtained from 30 glioma patients. To measure the degree to which the typical parameters of CP OCT images can be matched to the actual histology, 100 images of tumors and white matter were selected for visual analysis to be undertaken by three “single-blinded” investigators. An evaluation of the inter-rater reliability between the investigators was performed. Application of the identified visual CP OCT criteria for intraoperative use was performed during brain tumor resection in 17 patients. Results: The CP OCT image parameters that can typically be used for visual assessment were separated: (1) signal intensity; (2) homogeneity of intensity; (3) attenuation rate; (4) uniformity of attenuation. The degree of match between the CP OCT images and the histology of the specimens was significant for the parameters “signal intensity” in both polarizations, and “homogeneity of intensity” as well as the “uniformity of attenuation” in co-polarization. A test based on the identified criteria showed a diagnostic accuracy of 87–88%. Intraoperative in vivo CP OCT images of white matter and tumors have similar signals to ex vivo ones, whereas the cortex in vivo is characterized by indicative vertical striations arising from the “shadows” of the blood vessels; these are not seen in ex vivo images or in the case of tumor invasion. Conclusion: Visual assessment of CP OCT images enables tumorous and non-tumorous tissues to be distinguished. The most powerful aspect of CP OCT images that can be used as a criterion for differentiation between tumorous tissue and white matter is the signal intensity. In distinguishing white matter from tumors the diagnostic accuracy using the identified visual CP OCT criteria was 87–88%. As the CP OCT data is easily associated with intraoperative neurophysiological and neuronavigation findings this can provide valuable complementary information for the neurosurgeon tumor resection.

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“…The tumor response to therapy was assessed by a multimodal OCT system (designed at the Institute of Applied Physics RAS, Nizhny Novgorod) with a central wavelength of 1310 nm, power output of 15 mW, transversal resolution of 25 µm, axial resolution of 15 µm (in air), scanning depth of up to 2 mm in air and a scanning speed is 20,000 A-scans per second [28]. The system is capable of 2D cross-polarization imaging [29], 3D angiographic visualization [15,17,30,31], as well as imaging of local strains and quantitative stiffness evaluation using compressional elastography [32][33][34][35][36][37][38].…”

Section: Multimodal Oct Systemmentioning

confidence: 99%

In vivo assessment of functional and morphological alterations in tumors under treatment using OCT-angiography combined with OCT-elastography

Sirotkina

Gubarkova

Plekhanov

et al. 2020

Biomed. Opt. Express

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Emerging methods of anti-tumor therapies require new approaches to tumor response evaluation, especially enabling label-free diagnostics and in vivo utilization. Here, to assess the tumor early reaction and predict its long-term response, for the first time we apply in combination the recently developed OCT extensions-optical coherence angiography (OCA) and compressional optical coherence elastography (OCE), thus enabling complementary functional/microstructural tumor characterization. We study two vascular-targeted therapies of different types, (1) antiangiogenic chemotherapy (ChT) and (2) photodynamic therapy (PDT), aimed to indirectly kill tumor cells through blood supply injury. Despite different mechanisms of anti-angiogenic action for ChT and PDT, in both cases OCA demonstrated high sensitivity to blood perfusion cessation. The new method of OCE-based morphological segmentation revealed very similar histological structure alterations. The OCE results showed high correlation with conventional histology in evaluating percentages of necrotic and viable tumor zones. Such possibilities make OCE an attractive tool enabling previously inaccessible in vivo monitoring of individual tumor response to therapies without taking multiple biopsies.

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Noniterative method of reconstruction optical coherence tomography images with improved lateral resolution in semitransparent media

Cited by 18 publications

References 31 publications

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Quantitative nontumorous and tumorous human brain tissue assessment using microstructural co- and cross-polarized optical coherence tomography

Cross-Polarization Optical Coherence Tomography for Brain Tumor Imaging

In vivo assessment of functional and morphological alterations in tumors under treatment using OCT-angiography combined with OCT-elastography

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