Nonisomorphous X-Ray Structures of Tritylnitrile and Tritylisonitrile

Synthesis and crystal structure of 2-isocyano-4-methylphenyl diphenylacetate: a rare case of an easily accessible odourless isocyanide

“…In (I), the length of the N-C bond adjacent to the isocyanide group is 1.3908 (19) Å . A similar N-C bond distance of 1.388 (2) Å was observed for 2-benzyloxyphenyl isocyanide (Hahn & Lugger, 1997) and the average C-N bond distance adjacent to an isocyanide group is 1.422 Å (Skodje et al, 2012). Compound (I) displays a nearly linear isocyanide bond angle [177.97 (15) ] (Fig.…”

“…1). The average angle in the known isocyanide structures is 177.65 (Skodje et al, 2012). The -C( O)O-group lies out of the plane of the 2-isocyano-4-methylphenyl group.…”

“…The isocyanide group has an N1 C21 bond length of 1.164 (2) Å . The average length of the N C bond in the known structures of organic isocyanides is 1.151 Å (Skodje et al, 2012). Also, we compared the structure of (I) with that of 2-benzyloxyphenyl isocyanide because of their structural similarities.…”

Lewis Acid Catalyzed Synthesis of Cyanidophosphates

“…Surprisingly,w hen we used [Ph 3 C][PF 6 ]i nstead of [nBu 4 N][PF 6 ], an immediate violent reaction occurred at room temperatures on addition of Me 3 SiCN (10 equiv) and resulted in the exclusive formationo ft he [PF 2 (CN) 4 ] À ion as indicated by 19 Fa nd 31 PNMR experiments (Scheme 3, Table 1, and Supporting Information Ta bles S22 and S23). Extraction with n-hexanel ed to almostq uantitative isolation of Ph 3 CCN, which was identified unequivocally by X-ray diffraction (see Supporting Information), [16] but no pure [PF 2 (CN) 4 ] À salt could be obtained. Clearly, when Ph 3 CCN is formedq uantitatively,t hen Me 3 Si + remains as possible "cation", which, however,s hould form adducts of the type Me 3 Si-X-PF 2 (CN) 3 (X = Fo rC N).…”

Drug solid solutions – a method for tuning phase transformations

“…14 Solid solutions using whole organic molecules have been lightly investigated as highlighted by Cherukuvada and Nangia in their review of eutectic systems. 15 Examples of molecular solid solutions include benzoic acid/4-fluorobenzoic acid, 16 oxa-androgens, 17 indoloacridines, 18 and tritylnitrile/tritylisonitrile 19 systems although very few have investigated the change in physical properties beyond a change in melting point. This technique is readily used in the inorganic solid state literature in order to alter the properties of materials such as superconductors.…”