Noninvasive ventilation in hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease vs. other conditions: effectiveness and predictors of failure

Phua, Jason; Kong, Kien; Lee, Kang Hoe; Shen, Liang; Lim, Tow Keang

doi:10.1007/s00134-005-2582-8

Cited by 120 publications

(87 citation statements)

References 33 publications

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“…Previous studies have reported that (1) high acuity of illness (i.e., significant impairment in level of consciousness) (24), severe acidosis (pH , 7.25) (26,27), high APACHE II score (28), high SAPS score (24), the presence of complications from sepsis (24), and functional limitations before admission to the ICU (29) and (2) failure to demonstrate an early response to NIPPV (i.e., no improvement in pH, Pa CO 2 , and level of consciousness within 1 hour of initiation of NIPPV) (30) characterize patients likely to require IMV if initially treated with NIPPV. Therefore, two explanations might explain the high mortality rate in patients requiring IMV after NIPPV: (1) increasing the use of NIPPV in patients who are difficult to ventilate (29) and (2) continuation of NIPPV despite a lack of early improvement.…”

Section: Discussionmentioning

confidence: 99%

Outcomes of Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the United States, 1998–2008

Chandra

Stamm

Taylor

et al. 2012

Am J Respir Crit Care Med

361

262

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Rationale: The patterns and outcomes of noninvasive, positivepressure ventilation (NIPPV) use in patients hospitalized for acute exacerbations of chronic obstructive pulmonary disease (COPD) nationwide are unknown. Objectives: To determine the prevalence and trends of noninvasive ventilation for acute COPD. Methods: We used data from the Healthcare Cost and Utilization Project's Nationwide Inpatient Sample to assess the pattern and outcomes of NIPPV use for acute exacerbations of COPD from 1998 to 2008. Measurements and Main Results: An estimated 7,511,267 admissions for acute exacerbations occurred from 1998 to 2008. There was a 462% increase in NIPPV use (from 1.0 to 4.5% of all admissions) and a 42% decline in invasive mechanical ventilation (IMV) use (from 6.0 to 3.5% of all admissions) during these years. This was accompanied by an increase in the size of a small cohort of patients requiring transition from NIPPV to IMV. In-hospital mortality in this group appeared to be worsening over time. By 2008, these patients had a high mortality rate (29.3%), which represented 61% higher odds of death compared with patients directly placed on IMV (95% confidence interval, 24-109%) and 677% greater odds of death compared with patients treated with NIPPV alone (95% confidence interval, 475-948%). With the exception of patients transitioned from NIPPV to IMV, in-hospital outcomes were favorable and improved steadily year by year. Conclusions: The use of NIPPV has increased significantly over time among patients hospitalized for acute exacerbations of COPD, whereas the need for intubation and in-hospital mortality has declined. However, the rising mortality rate in a small but expanding group of patients requiring invasive mechanical ventilation after treatment with noninvasive ventilation needs further investigation.Keywords: COPD; positive-pressure ventilation; artificial respiration; epidemiology Chronic obstructive pulmonary disease (COPD) is the fourth leading cause of death in the United States and is projected to become the third leading cause of death by 2020 (1, 2). A large proportion of morbidity and mortality from COPD results from acute exacerbations, which lead to 1.5 million emergency room visits and 750,000 hospitalizations annually in the United States (3, 4). Therefore, to improve outcomes and reduce mortality due to COPD, we need to optimize the management of acute exacerbations (5), including the correct use of respiratory support modalities to treat patients with respiratory failure.Over the last decade, noninvasive, positive-pressure ventilation (NIPPV) has started playing an increasingly important role in the treatment of respiratory failure due to acute exacerbations (6-12). This is because clinical trials demonstrate good efficacy for NIPPV in reducing risk of intubation and mortality, health care providers are becoming increasingly confident with its use, and unlike IMV, it can be implemented outside the ICU, freeing up ICU beds. Therefore, it appears likely that NIPPV use will continue to increa...

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Section: Discussionmentioning

confidence: 99%

Outcomes of Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the United States, 1998–2008

Chandra

Stamm

Taylor

et al. 2012

Am J Respir Crit Care Med

361

262

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“…Out of 3 patients of Bronchiectasis and 1 patient of ILD no one required invasive ventilation. Phua J et al [23] reported that risk of NIV failure was lower in COPD than in other condition (19% vs 47%) respectively. In a study done by Schettino et al [24] , intubation rate was 18%, 24%, 38%, 40%, and 60%, respectively, for patients with cardiogenic pulmonary edema, acute exacerbation of COPD, acute hypercapnic respiratory failure, post extubation respiratory failure patients and acute hypoxemic respiratory failure.…”

Section: Discussionmentioning

confidence: 97%

“…Phua et al [23] found that NIV was more effective in preventing endotracheal intubation in hypercapnic ARF due to COPD than non-COPD conditions. In the study by Yoshida et al [26] studied a total of 47 patients with ALI who received NIV, and 33 patients (70%) successfully avoided endotracheal intubation.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Noninvasive Positive Pressure Ventilation in the Management of Acute Respiratory Failure

A¹

2017

JMSCR

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“…In severe COPD patients, exacerbations are frequently associated with acute hypercapnic respiratory failure, which require ventilatory support and hospitalization (2). Despite advances in NIV procedures -which are now considered as the standard treatment for respiratory failure associated with acute COPD exacerbations -these methods prove insufficient in nearly 15-26% of patients with acute exacerbations, who consequently require a transition from NIV to IMV (3,4).…”

Section: Introductionmentioning

confidence: 99%

Removal of extracorporeal carbon dioxide in chronic obstructive pulmonary disease patients

Bozkuş

Bilal²,

Öksüz³

2016

Tuberk Toraks

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Noninvasive ventilation in hypercapnic acute respiratory failure due to chronic obstructive pulmonary disease vs. other conditions: effectiveness and predictors of failure

Cited by 120 publications

References 33 publications

Outcomes of Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the United States, 1998–2008

Outcomes of Noninvasive Ventilation for Acute Exacerbations of Chronic Obstructive Pulmonary Disease in the United States, 1998–2008

Effectiveness of Noninvasive Positive Pressure Ventilation in the Management of Acute Respiratory Failure

Removal of extracorporeal carbon dioxide in chronic obstructive pulmonary disease patients

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