Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma

Linnik, Inna V.; Scott, Marietta; Holliday, Katherine Frances; Woodhouse, Neil; Waterton, John C.; O’Connor, James P.B.; Barjat, Hervé; Liess, Carsten; Ulloa, Jose L.; Young, Helen; Dive, Caroline; Hodgkinson, Cassandra L.; Ward, Tim; Roberts, D. F.; Mills, Samantha J.; Thompson, Gerard; Buonaccorsi, Giovanni A.; Cheung, Susan; Jackson, Alan; Naish, Josephine H.; Parker, Geoffrey

doi:10.1002/mrm.24826

Cited by 57 publications

(79 citation statements)

References 45 publications

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“…Here, O'Connor found linear correlations between pimonidazole binding and~R 1 . This type of correlation has also been observed in a brain tumor model (36). O'Connor also demonstrated that correction for perfusion may be necessary for tumors that exhibit extensive necrosis.…”

Section: Imaging Of Hypoxia Is the Solution For Selecting Patients Fosupporting

confidence: 53%

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging

Dewhirst

Birer

2016

Cancer Research

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Section: Imaging Of Hypoxia Is the Solution For Selecting Patients Fosupporting

confidence: 53%

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging

Dewhirst

Birer

2016

Cancer Research

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“…Optical imaging techniques are capable of measuring oxygenation, but are severely limited in their penetration depth and spatial resolution due to the dominance of ballistic photon scattering [17]. Blood Oxygenation Level Dependent contrast (BOLD) MRI and oxygen-enhanced (OE) MRI are the only clinical imaging modalities capable of assessing volumetric tumour oxygenation [18–20]. However, these techniques are limited by their cost and accessibility which renders them impractical for assessing the early changes in oxygenation.…”

Section: Introductionmentioning

confidence: 99%

Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes

et al. 2016

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Imaging methods capable of indicating the potential for success of an individualized treatment course, during or immediately following the treatment, could improve therapeutic outcomes. Temperature Sensitive Liposomes (TSLs) provide an effective way to deliver chemotherapeutics to a localized tumoral area heated to mild-hyperthermia (HT). The high drug levels reached in the tumor vasculature lead to increased tumor regression via the cascade of events during and immediately following treatment. For a TSL carrying doxorubicin (DOX) these include the rapid and intense exposure of endothelial cells to high drug concentrations, hemorrhage, blood coagulation and vascular shutdown. In this study, ultrasound-guided photoacoustic imaging was used to probe the changes to tumors following treatment with the TSL, HaT-DOX (Heat activated cytoToxic). Levels of oxygen saturation (sO2) were studied in a longitudinal manner, from 30 min pre-treatment to 7 days post-treatment. The efficacious treatments of HT-HaT-DOX were shown to induce a significant drop in sO2 (>10%) as early as 30 min post-treatment that led to tumor regression (in 90% of cases); HT-Saline and non-efficacious HT-HaT-DOX (10% of cases) treatments did not show any significant change in sO2 at these timepoints. The changes in sO2 were further corroborated with histological data, using the vascular and perfusion markers CD31 and FITC-lectin. These results allowed us to further surmise a plausible mechanism of the cellular events taking place in the TSL treated tumor regions over the first 24 hours post-treatment. The potential for using photoacoustic imaging to measure tumor sO2 as a surrogate prognostic marker for predicting therapeutic outcome with a TSL treatment is demonstrated.

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“…Several preliminary studies have already shown the use of hyperoxic gas challenge to stimulate BOLD and/or TOLD MRI signal responses in tumors at distinct disease sites (breast [56, 57], cervix [49, 58, 59], brain [38, 60], prostate [61], and liver [62]). Breathing oxygen is particularly appropriate, since this is standard intervention in emergency medicine and thus it is quite straightforward to gain IRB approval.…”

Section: Discussionmentioning

confidence: 99%

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response

White

Zhang

et al. 2016

Cancer Letters

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Oxygen-Enhanced Magnetic Resonance Imaging (OE-MRI) techniques were evaluated as potential non-invasive predictive biomarkers of radiation response. Semi quantitative blood-oxygen level dependent (BOLD) and tissue oxygen level dependent (TOLD) contrast, and quantitative responses of relaxation rates (ΔR1 and ΔR2*) to an oxygen breathing challenge during hypofractionated radiotherapy were applied. OE-MRI was performed on subcutaneous Dunning R3327-AT1 rat prostate tumors (n = 25) at 4.7 T prior to each irradiation (2Fx15 Gy) to the gross tumor volume. Response to radiation, while inhaling air or oxygen, was assessed by tumor growth delay measured up to four times the initial irradiated tumor volume (VQT). Radiation-induced hypoxia changes were confirmed using a double hypoxia marker assay. Inhaling oxygen during hypofractionated radiotherapy significantly improved radiation response. A correlation was observed between the difference in the 2nd and 1st ΔR1 (ΔΔR1) and VQT for air breathing rats. The TOLD response before the 2nd fraction showed a moderate correlation with VQT for oxygen breathing rats. The correlations indicate useful prognostic factors to predict tumor response to hypofractionation and could readily be applied for patient stratification and personalized radiotherapy treatment planning.

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Noninvasive tumor hypoxia measurement using magnetic resonance imaging in murine U87 glioma xenografts and in patients with glioblastoma

Abstract: These data support further investigation of T1 -weighted OE-MRI to identify regional tumor hypoxia. The quantification of AUCOE has translational potential as a clinical biomarker of hypoxia.

Cited by 57 publications

References 45 publications

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging

Oxygen-Enhanced MRI Is a Major Advance in Tumor Hypoxia Imaging

Photoacoustic Imaging of Cancer Treatment Response: Early Detection of Therapeutic Effect from Thermosensitive Liposomes

Developing oxygen-enhanced magnetic resonance imaging as a prognostic biomarker of radiation response

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