Noninvasive transcranial focal stimulation affects the convulsive seizure-induced P-glycoprotein expression and function in rats

Pérez-Pérez, Daniel; Castañeda‐Cabral, José Luis; Orozco‐Suárez, Sandra; Sotelo, Julio; Besio, Walter G.; Rocha, Luisa

doi:10.1016/j.yebeh.2020.107659

Cited by 10 publications

(7 citation statements)

References 58 publications

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“…TCREs are safe for stimulation [20,21] and can be used for seizure control [22][23][24][25][26]. The stimulation can block epileptogenesis [27] and alter neurotransmitters to increase the effectiveness of anti-seizure drugs [28][29][30]. Stimulation experiments are underway to determine if transcranial focal stimulation via concentric ring electrodes is effective for modulating human brains.…”

Section: Focal Bi-directional Brain Computer Interfacing With Concent...mentioning

confidence: 99%

Workshops of the eighth international brain–computer interface meeting: BCIs: the next frontier

Huggins

Krusienski

Vansteensel

et al. 2022

Brain-Computer Interfaces

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The Eighth International Brain-Computer Interface (BCI) Meeting was held June 7-9, 2021 in a virtual format. The conference continued the BCI Meeting series' interactive nature with 21 workshops covering the breadth of topics in BCI (also called brain-machine interface) research. Some workshops provided detailed examinations of methods, hardware, or processes. Others focused on BCI applications or user groups. Several workshops continued consensus building efforts designed to create BCI standards and improve comparisons between studies and the potential for meta-analysis and large multi-site clinical trials. Ethical and translational considerations were the primary topic for some workshops or an important secondary consideration for others. The range of BCI applications continues to expand, with more workshops focusing on approaches that can extend beyond the needs of those with physical impairments. This paper summarizes each workshop, provides background information and references for further study, summarizes discussions, and describes the resulting conclusion, challenges, or initiatives.

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Section: Focal Bi-directional Brain Computer Interfacing With Concent...mentioning

confidence: 99%

Workshops of the eighth international brain–computer interface meeting: BCIs: the next frontier

Huggins

Krusienski

Vansteensel

et al. 2022

Brain-Computer Interfaces

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“…Transcranial focal stimulation (TFS), a noninvasive neuromodulation strategy, has been shown to reduce seizure activities and avoid P-gp overexpression in different experimental models. According to these, it is indicated that TFS may also represent a new neuromodulatory strategy to revert secondary epileptogenesis ( 114 ).…”

Section: Available and Potential Treatments For Secondary Epileptogenesismentioning

confidence: 99%

Secondary Epileptogenesis: Common to See, but Possible to Treat?

et al. 2021

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Secondary epileptogenesis is a common phenomenon in epilepsy, characterized by epileptiform discharges from the regions outside the primary focus. It is one of the major reasons for pharmacoresistance and surgical failure. Compared with primary epileptogenesis, the mechanism of secondary epileptogenesis is usually more complex and diverse. In this review, we aim to summarize the characteristics of secondary epileptogenesis from both clinical and laboratory studies in a historical view. Mechanisms of secondary epileptogenesis in molecular, cellular, and circuity levels are further presented. Potential treatments targeting the process are discussed as well. At last, we highlight the importance of circuitry studies, which would further illustrate precise treatments of secondary epileptogenesis in the future.

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“…TFS focuses on the electrical stimulation, with a uniform current density, directly below the electrode generating electric fields in subcortical regions without adverse effects [ 29 , 30 , 31 , 32 , 33 ]. TFS reduce the convulsive activity induced by several drugs [ 34 , 35 , 36 , 37 , 38 ]. Santana-Gómez and colleagues found that TFS reduced the seizure activity and lessens the excessive glutamate release during pilocarpine-induced status epilepticus [ 39 ].…”

Section: Introductionmentioning

confidence: 99%

“…Meanwhile, Pérez-Pérez and colleagues found that TFS restitutes the anticonvulsive effects of phenytoin in an animal model of pharmacoresistant seizures with P-gp overexpression. In addition, these authors found that TFS applied before the induction of a single generalized seizure avoids P-gp overexpression in both hippocampi and cerebral cortices [ 38 ]. Concerning epileptogenesis, it was found that TFS applied immediately after each electrical amygdala kindling (EAK) stimulation avoids the evolution of this process in cats, and this effect lasted several weeks after TFS cessation [ 40 ].…”

Section: Introductionmentioning

confidence: 99%

Transcranial Focal Electric Stimulation Avoids P-Glycoprotein Over-Expression during Electrical Amygdala Kindling and Delays Epileptogenesis in Rats

Fonseca-Barriendos

Castañeda‐Cabral

Martínez-Cuevas

et al. 2023

Life

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Recent evidence suggests that P-glycoprotein (P-gp) overexpression mediates hyperexcitability and is associated with epileptogenesis. Transcranial focal electrical stimulation (TFS) delays epileptogenesis and inhibits P-gp overexpression after a generalized seizure. Here, first we measured P-gp expression during epileptogenesis and second, we assessed if TFS antiepileptogenic effect was related with P-gp overexpression avoidance. Male Wistar rats were implanted in right basolateral amygdala and stimulated daily for electrical amygdala kindling (EAK), P-gp expression was assessed during epileptogenesis in relevant brain areas. Stage I group showed 85% increase in P-gp in ipsilateral hippocampus (p < 0.001). Stage III group presented 58% and 57% increase in P-gp in both hippocampi (p < 0.05). Kindled group had 92% and 90% increase in P-gp in both hippocampi (p < 0.01), and 93% and 143% increase in both neocortices (p < 0.01). For the second experiment, TFS was administrated daily after each EAK stimulation for 20 days and P-gp concentration was assessed. No changes were found in the TFS group (p > 0.05). Kindled group showed 132% and 138% increase in P-gp in both hippocampi (p < 0.001) and 51% and 92% increase in both cortices (p < 0.001). Kindled + TFS group presented no changes (p > 0.05). Our experiments revealed that progression of EAK is associated with increased P-gp expression. These changes are structure-specific and dependent on seizure severity. EAK-induced P-gp overexpression would be associated with neuronal hyperexcitability and thus, epileptogenesis. P-gp could be a novel therapeutical target to avoid epileptogenesis. In accordance with this, TFS inhibited P-gp overexpression and interfered with EAK. An important limitation of the present study is that P-gp neuronal expression was not evaluated under the different experimental conditions. Future studies should be carried out to determine P-gp neuronal overexpression in hyperexcitable networks during epileptogenesis. The TFS-induced lessening of P-gp overexpression could be a novel therapeutical strategy to avoid epileptogenesis in high-risk patients.

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Noninvasive transcranial focal stimulation affects the convulsive seizure-induced P-glycoprotein expression and function in rats

Cited by 10 publications

References 58 publications

Workshops of the eighth international brain–computer interface meeting: BCIs: the next frontier

Workshops of the eighth international brain–computer interface meeting: BCIs: the next frontier

Secondary Epileptogenesis: Common to See, but Possible to Treat?

Transcranial Focal Electric Stimulation Avoids P-Glycoprotein Over-Expression during Electrical Amygdala Kindling and Delays Epileptogenesis in Rats

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