Noninvasive serum models to predict significant liver related events in chronic hepatitis C

Abstract

Some simple pretreatment blood parameters and NIFS showed high accuracy for predicting development of SLRE post treatment. Application of these simple scores can improve assessment of long-term liver prognosis for CHC.

Persistence of hepatocellular carcinoma risk in hepatitis C patients with a response to IFN and cirrhosis regression

“…Different serum biomarkers have been retrospectively analysed, in all cases without any correlation with histology, and studies provided discordant results. In fact, Toyoda and colleagues found that low pre‐treatment Forns Score values were protective against the risk of liver cancer, whereas none of the 20 tests analysed in the study by Thandassery et al reached any significant predictive value at multivariate analysis . On the contrary, we found that Forns Score, Lok Index and PLF values above the viremic F4 cut‐off were associated with an increased risk of HCC.…”

“…In fact, Toyoda and colleagues 38 found that low pre-treatment Forns Score values were protective against the risk of liver cancer, whereas none of the 20 tests analysed in the study by Thandassery et al reached any significant predictive value at multivariate analysis. 39 On the contrary, we found that Forns Score, Lok Index and PLF values above the viremic F4 cut-off were associated with an increased risk of HCC. Although these data have been obtained in a much selected cohort, thus preventing us from assessing NITs real predictive values, we think that this aspect needs further external large validation.…”

“…Among them, Forns Score includes γGT, age and cholesterol which have been previously demonstrated to be associated with an increased risk of HCC after an SVR. This is an important finding, since scarce data exist on the correlation between post‐SVR NIT values and residual risk of HCC in non‐ viremic patients . Different serum biomarkers have been retrospectively analysed, in all cases without any correlation with histology, and studies provided discordant results.…”

“…This is an important finding, since scarce data exist on the correlation between post-SVR NIT values and residual risk of HCC in non-viremic patients. 38,39 Different serum biomarkers have been retrospectively analysed, in all cases without any correlation with histology, and studies provided discordant results.…”

Prognostic Value of Noninvasive Fibrosis Scores in Primary Biliary Cholangitis

“…These noninvasive score systems have also been shown a good prognostic value for prognosis of patients with chronic hepatitis C (CHC). 12 However, only a few studies in literature have evaluated prognostic value of NIFS for the long-term survival of PBC population.…”