Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept

Ku, Min-Chi; Fernández‐Seara, María A.; Kober, Frank; Niendorf, Thoralf

doi:10.1007/978-1-0716-0978-1_13

Cited by 5 publications

(3 citation statements)

References 31 publications

(29 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Overall cortical renal allograft blood flow in our patient group, as measured with ASL, ranged between 85 and 303 mL/100 g/min (mean 183.06 ± 61.66 mL/100 g/min) and it was comparable with previously reported results on transplanted and native kidneys 1 , 2 , 5 , 14 – 16 , 20 , 27 – 35 . As the mean GFR and mean cRBF value showed no statistically significant difference in comparison to the allograft donor type ( p = 0.225 and p = 0.262, respectively), this allograft characteristic was then considered as uniform in all patients, without statistically significant influence on allograft function.…”

Section: Discussionsupporting

confidence: 89%

“…In recent years, arterial spin labelling (ASL) MRI has been applied in various anatomical regions to estimate tissue perfusion. This MRI technique uses arterial blood water as a freely diffusible natural tracer to track and quantify tissue perfusion 3 , 4 , 14 – 16 . It is considered completely safe and non-invasive, with high potential in assessing renal allograft function.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)

Radović

Janković

Stevic

et al. 2022

Sci Rep

View full text Add to dashboard Cite

The study aimed to discriminate renal allografts with impaired function by measuring cortical renal blood flow (cRBF) using magnetic resonance imaging arterial spin labelling (ASL-MRI) in paediatric and young adult patients. We included 18 subjects and performed ASL-MRI on 1.5 T MRI to calculate cRBF on parameter maps. cRBF was correlated to calculated glomerular filtration rate (GFR) and compared between patient groups with good (GFR ≥ 60 mL/min/1.73 m2) and impaired allograft function (GFR < 60 mL/min/1.73 m2). Mean cRBF in patients with good allograft function was significantly higher than in patients with impaired allograft function (219.89 ± 57.24 mL/min/100 g vs. 146.22 ± 41.84 mL/min/100 g, p < 0.008), showing a highly significant correlation with GFR in all subjects (r = 0.75, p < 0.0001). Also, the diffusion-weighted imaging (DWI-MRI) apparent diffusion coefficient (ADC) and Doppler measurements of peak-systolic and end-diastolic velocities and the resistive index (PS, ED, RI) were performed and both methods showed no significant difference between groups. ADC implied no correlation with GFR (r = 0.198, p = 0.464), while PS indicated moderate correlation to GFR (r = 0.48, p < 0.05), and PS and ED moderate correlation to cRBF (r = 0.58, p < 0.05, r = 0.56, p < 0.05, respectively). Cortical perfusion as non-invasively measured by ASL-MRI differs between patients with good and impaired allograft function and correlates significantly with its function.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)

Radović

Janković

Stevic

et al. 2022

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) was first applied to the study of transplanted kidneys in 2005 and has undergone several changes in technical parameters and measurement indexes since this time. The imaging method is based on changes in the distribution of blood oxygen levels within the tissue, and it is the only method in current clinical studies that can assess the distribution of blood oxygen levels in living transplanted kidneys under non-invasive conditions, thus reflecting their internal oxygenation status ( 3 , 4 ). The hemoglobin in normal blood is divided into deoxyhemoglobin and oxygenated hemoglobin, which have opposite magnetic properties, the former being paramagnetic and the latter being inverse magnetic, and this property is used to cause a magnetic field gradient change in the water molecules around and inside the blood vessel.…”

Section: Introductionmentioning

confidence: 99%

A clinical study of using ROC to compare the efficiency of ASL and BOLD in diagnosis of renal allograft function

Jin¹,

Yang²,

Zhu³

et al. 2023

Transl Androl Urol

View full text Add to dashboard Cite

Background: This retrospective study aims to evaluate the effectiveness of renal transplantation function by comparing arterial spin labeling (ASL) and blood oxygen level dependent (BOLD) imaging with the receiver operating characteristic (ROC) curve.Methods: According to the estimated glomerular filtration rate (eGFR) values, 42 patients with normal kidney grafts (the normal kidney graft group, eGFR <60 mL/min/1.73 m 2 ) and 93 patients with injured grafts (the kidney graft injury group, eGFR <60 mL/min/1.73 m 2 ) were included in the present study. Renal blood flow (RBF) and the effective transverse relaxation rate (R2*) were calculated by comparing ASL and BOLD imaging. The ROC curve and the youden index were used to evaluate the diagnostic performance of ASL, BOLD, and the combination of them. Results:The results showed that all the clinical features of the patients, except for gender, differed significantly between the 2 groups (P<0.05). The mean RBF value of the renal transplant injury group (104.33±54.76 mL/100 g/min) was significantly lower than that of the normal group (191.84±63.96 mL/ 100 g/min, P<0.01). The mean medullary R2* value of the renal transplant injury group (27.91±3.35 1/s) was significantly higher than that of the normal group (25.22±2.94 1/s, P<0.01). Negative correlations were found between R2* and eGFR (r=-0.44), and RBF and R2* (r=-0.54; both P<0.01). The ROC analysis showed that both RBF and R2* reflected injured renal function [area under the curves (AUC) =0.86 and 0.72, respectively]. In addition, the AUC of RBF and R2* combined was 0.86, which was comparable to that of RBF alone (P=0.95), while combining R2* and RBF improved the diagnostic performance of R2* alone (AUC =0.86 versus 0.72, respectively; P<0.01). The youden index analysis showed that the diagnostic accuracy of ASL was 80.00%, better than 71.85% of BOLD; the sensitivity and specificity of ASL in diagnosing renal allograft dysfunction were 79.57% and 80.95%, superior to 77.42% and 59.52% of BOLD.Conclusions: Our results showed that the non-invasive assessment of ASL in clinical kidney transplant function is a more promising imaging technique than BOLD.

show abstract

The value of functional magnetic resonance imaging in evaluating renal allograft function

Peng,

Gao,

Hong

et al. 2024

Asian Journal of Surgery

View full text Add to dashboard Cite

Noninvasive Renal Perfusion Measurement Using Arterial Spin Labeling (ASL) MRI: Basic Concept

Cited by 5 publications

References 31 publications

Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)

Detection of impaired renal allograft function in paediatric and young adult patients using arterial spin labelling MRI (ASL-MRI)

A clinical study of using ROC to compare the efficiency of ASL and BOLD in diagnosis of renal allograft function

The value of functional magnetic resonance imaging in evaluating renal allograft function

Contact Info

Product

Resources

About