Noninvasive radiofrequency ablation of cancer targeted by gold nanoparticles

Cardinal, Jon; Klune, John R.; Chory, Eamon; Jeyabalan, Geetha; Kanzius, John S.; Nalesnik, Michael A.; Geller, David A.

doi:10.1016/j.surg.2008.03.036

Cited by 180 publications

(174 citation statements)

References 29 publications

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“…• endoscopic delivery, whereby gold nanoparticles can be delivered with the assistance of a microendoscope via a needle and protective sheath; near infrared light exposure is successfully performed using a microfiber probe integrated with a laser system in the esophageal lumen; and endoscopic delivery may conceivably provide the opportunity to ablate esophageal cancer in patients who are not candidates for surgery • two techniques which are each innocuous until combined, with near infrared light exposure not affecting normal esophageal tissue unless it was loaded with CS-GGS nanoparticles, suggesting that gold nanoparticles coupled with near infrared light exposure could enable thermalbased ablation targeted specifically at cancerous tissue, which is consistent with other reports 14 • an ability to target cancer cells selectively, as indicated in vitro by the high affinity of malignant OE-19 cells for CS-GGS nanoparticles, whereas the two benign cell lines, ie, BAR-T and HET-1A cells, showed less affinity; the differential uptake of CS-GGS between cancerous and benign tissue could enable targeted destruction of only cancerous tissue. There are questions that remain to be answered, as well as technical obstacles to be overcome in future studies.…”

supporting

confidence: 87%

Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Li¹,

Gobin²,

Dryden³

et al. 2013

IJN

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Gold nanoparticles and near infrared-absorbing light are each innocuous to tissue but when combined can destroy malignant tissue while leaving healthy tissue unharmed. This study investigated the feasibility of photothermal ablation therapy for esophageal adenocarcinoma using chitosan-coated gold/gold sulfide (CS-GGS) nanoparticles. A rat esophagoduodenal anastomosis model was used for the in vivo ablation study, and three human esophageal cell lines were used to study the response of cancer cells and benign cells to near infrared light after treatment with CS-GGS. The results indicate that both cancerous tissue and cancer cells took up more gold nanoparticles and were completely ablated after exposure to near infrared light. The benign tissue and noncancerous cells showed less uptake of these nanoparticles, and remained viable after exposure to near infrared light. CS-GGS nanoparticles could provide an optimal endoluminal therapeutic option for near infrared light ablation of esophageal cancer.

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supporting

confidence: 87%

Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Li¹,

Gobin²,

Dryden³

et al. 2013

IJN

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“…The minimum temperature for therapeutic benefit was above 42˚C. Above 46˚C the time for cell killing becomes quite short and the different sensitivity of malignant and benign cells disappears; above 50˚C all cells are killed very quickly (15). In the capacitive heating technique, the current spread can also cause excessive surface heating by the output of high power, so it is impossible for a therapeutic temperature of 46-50˚C to be used.…”

Section: Discussionmentioning

confidence: 99%

Magnetic fluid hyperthermia induced by radiofrequency capacitive field for the treatment of transplanted subcutaneous tumors in rats

Rong

Jin

et al. 2011

Experimental and Therapeutic Medicine

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Abstract. Magnetic fluid hyperthermia (MFH) induced by a magnetic field has become a new heating technology for the treatment of malignant tumors due to its ability to heat the tumor tissue precisely and properly, and due to its significant therapeutic effects. In this study, MFH induced by radiofrequency capacitive field (RCF) for the treatment of transplanted subcutaneous tumors in rats, was investigated. A total of 50 rats bearing subcutaneous tumors were randomly divided into five groups, including i) a pseudo-treatment (PT) control group, ii) magnetic fluid (MF) group, iii) pure hyperthermia (PH) group, iv) magnetic fluid hyperthermia 1 (MFH1) group, and v) magnetic fluid hyperthermia 2 (MFH2) group. Tumors were irradiated for 30 min in the MFH1 group 24 h following injection of MF. Tumors were irradiated for 30 min in the MFH2 group 24 h following injection of MF, and irradiation was repeated for 30 min 72 h following injection of MF. Tumor volumes, tumor volume inhibition ratios and survival times in the rat model were examined. Temperatures of tumor cores and rims both rapidly reached the desired temperature (~50˚C) for tumor treatment within 5 to 10 min in the MFH1 and MFH2 groups, and we maintained this temperature level by manually adjusting the output power (70-130 W). Tumor volumes of the MFH1 and MFH2 groups were reduced compared to those of the PT, MF and PH groups. The inhibitory effect on tumor growth in the MFH2 group (91.57%) was higher compared to that in the MFH1 group (85.21%) and the other groups. The survival time of the MFH2 group (51.62±2.28 days) and MFH1 group (43.10±1.57 days) was increased compared to that of the PH, MF and PT groups. The results obtained show that MFH induced by RCF may serve as a potential and promising method for the treatment of tumors.

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“…3 Alternately, because of the relatively low penetration depth of radiation at infrared (IR) and visible frequencies, radio frequency (RF) energy has been suggested for biomedical applications because it penetrates easily in the human body, thus reaching important internal organs. A series of papers [4][5][6][7][8][9][10][11][12] has considered RF heating of gold nanoparticles, showing significant heating. However, a recent experiment 13 contradicts this, and finds that gold nanoparticles at RF do not heat.…”

Section: Introductionmentioning

confidence: 99%

Electromagnetic absorption mechanisms in metal nanospheres: Bulk and surface effects in radiofrequency-terahertz heating of nanoparticles

Hanson

Monreal

Apell

2011

Journal of Applied Physics

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We report on the absorption of electromagnetic radiation by metallic nanoparticles in the radio and far infrared frequency range, and subsequent heating of nanoparticle solutions. A recent series of papers has measured considerable radio frequency (RF) heating of gold nanoparticle solutions. In this work, we show that claims of RF heating by metallic nanoparticles are not supported by theory. We analyze several mechanisms by which nonmagnetic metallic nanoparticles can absorb low frequency radiation, including both classical and quantum effects. We conclude that none of these absorption mechanisms, nor any combination of them, can increase temperatures at the rates recently reported. A recent experiment supports this finding.

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Noninvasive radiofrequency ablation of cancer targeted by gold nanoparticles

Cited by 180 publications

References 29 publications

Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Infrared light-absorbing gold/gold sulfide nanoparticles induce cell death in esophageal adenocarcinoma

Magnetic fluid hyperthermia induced by radiofrequency capacitive field for the treatment of transplanted subcutaneous tumors in rats

Electromagnetic absorption mechanisms in metal nanospheres: Bulk and surface effects in radiofrequency-terahertz heating of nanoparticles

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