Noninvasive quantitative fluorodeoxyglucose PET studies with an estimated input function derived from a population-based arterial blood curve.

Abstract

The authors have developed a technique to estimate input functions from a population-based arterial blood curve in positron emission tomography (PET) studies with fluorine-18 fluorodeoxyglucose (FDG). A standardized pump injection was used in 34 subjects. A population-based blood curve was generated based on the first 10 subjects. In the remaining 24 subjects, an estimated input function (EIFa) was obtained by scaling the population-based curve with two arterial blood samples, one obtained at 10 minutes and the other at 45. Time integrals for EIFa and the real arterial input function (RIF) were in excellent agreement (r = .998, P < .0001). Cerebral metabolic rates for glucose calculated with EIFa and RIF and the autoradiographic method also correlated excellently (r = .992, P < .0001). Analogous correlations were achieved with arterialized venous samples as scaling factors. These results suggest that individually scaled, population-derived input functions may serve as an adequate alternative to continuous arterial blood sampling in quantitative FDG-PET imaging.

Image-Derived Input Function for Brain PET Studies: Many Challenges and Few Opportunities

“…For tracers with metabolites, PBIF refers to the serial concentrations over time of the parent radioligand separated from radiometabolites. Population-based input function has been validated mostly for [ 18 F]-FDG, using arterial (Takikawa et al, 1993) or venous blood samples (Takagi et al, 2004) as scaling factors, or using noninvasive individual parameters such as body surface area (Shiozaki et al, 2000) or cerebellar [ 18 F]-FDG activity (Bentourkia, 2006). Studies with other PET tracers are very rare (Beattie et al, 2010;Cook et al, 1999;Takikawa et al, 1994).…”

Systemic and Nasal Delivery of Orexin-A (Hypocretin-1) Reduces the Effects of Sleep Deprivation on Cognitive Performance in Nonhuman Primates

“…A population-averaged FDG blood curve (calculated for monkey) was scaled to the measured blood curve for the time period from injection to the end of the PET scan (Takikawa et al, 1993). Data were transformed to CMRglc based on the operational equation (Sokoloff et al, 1977;Phelps et al, 1979).…”

High-resolution18F-FDG PET/CT for assessing disease activity in rheumatoid and psoriatic arthritis: findings of a prospective pilot study

“…Dynamic PET data collection was not feasible in our system because of its step-andshoot acquisition protocol. This limitation has been addressed in a next-generation system, 42 where investigators could optionally employ a population-based arterial input function 45 or arterial blood sampling. Kinetic parameters thus derived could reveal new knowledge about RA or PsA pathogenesis.…”