Noninvasive Presurgical Data for One-Stage Leucotomy in Catastrophic Epilepsy

Park, Jun; Vaca, Guadalupe Fernandez‐Baca; Tangen, Rachel; Cohen, Mark L.; Miller, Jonathan P.

doi:10.1016/j.wneu.2018.05.182

Cited by 2 publications

(1 citation statement)

References 4 publications

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“…In the presence of more than four factors, 91% were found to be surgical candidates [6]. Therefore, early surgery is recommended for those who are suitable for surgery in order to avoid intellectual and cognitive deterioration [7,8]. The surgical treatment of IS mainly includes two methods: resection and palliative surgery.…”

Section: Discussionmentioning

confidence: 99%

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Yang

Peng

et al. 2020

Acta Epileptologica

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Background Infantile spasms (IS) are the most common childhood epileptic encephalopathy. Focal cortical dysplasia (FCD) and gray matter heterotopias (GH) are common structural causes of IS. The recommended first-line treatment for IS patients with structural causes is surgical intervention, according to the International League Against Epilepsy (ILAE) commission guidelines. However, there is currently no consensus on appropriate timings of surgery. Case presentations Two structural IS cases are presented here: one was caused by FCD, and the other by GH. Both patients exhibited recurrent seizures at the age of 2 months, had poor responses to various antiepileptic drugs (AEDs) and displayed severe mental and motor developmental retardation. Seizure types included focal seizures and spasms. Brain magnetic resonance imaging showed abnormal gray signal or suspicious FCD lesions that coincided with the origin of the focal seizures. The patients underwent lesion resection before the age of 6 months. Follow-up observation showed that seizures of both patients were completely controlled several days after the surgery. All AEDs were gradually reduced in dosage within 1 year, and the mental and motor development almost returned to normal. Conclusion Early resection of lesions in structural IS patients has benefits of effectively controlling convulsions and improving developmental retardation. Infants at several months of age can well tolerate craniotomy, and their cognitive development is more likely to return to normal after early surgery.

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Section: Discussionmentioning

confidence: 99%

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Yang

Peng

et al. 2020

Acta Epileptologica

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Long-term follow-up in patients with catastrophic epilepsies

Firsov

Котов

2019

RJTAO

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Objective: to investigate the features of the course and long-term outcome of catastrophic epilepsies. Patients and methods. A total of 130 patients (62 (47.7%) men and 68 (52.3%) women) aged 21 to 78 years were examined. The follow-up was 1 year to 14 years. The inclusion criteria for the investigation were above 18 years of age; severe epilepsy with daily seizures considered as catastrophic epilepsy. The exclusion criteria were a history of nonepileptic seizures of any etiology, as well as noncompliance. The examination included history data collection; seizure diary analysis; clinical and neurological examination; routine EEG and/or EEG-video monitoring; brain magnetic resonance imaging; and laboratory tests. Results and discussion. The onset of epilepsy immediately with catastrophic seizures was observed in 28 (21.5%) patients; this onset was most frequently seen in 18 of the 28 children. At the same time, catastrophic seizures did not appear immediately, but it took some time for them to occur after the onset of active epilepsy in 102 (78.5%) patients. Moreover, the onset of catastrophic seizures could not be associated with any external influences or errors in 58 (56.9%) of these patients taking the drugs. Transition to catastrophic epilepsy could occur both abruptly in 11 (10.8%) patients and gradually in 91 (89.2%). After treatment correction, 16.8% of patients achieved remission at the time of study completion; the frequency of seizures decreased by 50% or more in 27.1% of cases; the effect was absent in 56.1%. Conclusion. Based on the findings, it can be concluded that in catastrophic epilepsy, the probability exists for spontaneous occurrence and remission of destructive seizures, frequently regardless of the therapy. The onset of the disease and that of catastrophic seizures can be spread in time. The efficiency of treatment remains low in patients with catastrophic epilepsies.

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Noninvasive Presurgical Data for One-Stage Leucotomy in Catastrophic Epilepsy

Cited by 2 publications

References 4 publications

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Early surgical intervention for structural infantile spasms in two patients under 6 months old: a case report

Long-term follow-up in patients with catastrophic epilepsies

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