Noninvasive predictors of hepatic fibrosis in patients with chronic hepatitis C virus in comparison with liver biopsy

Menessy, Ayman; Ahmed, Nancy Abdel Fattah; Abdallah, Nagwa I; Arif, Salah S.

doi:10.4103/bmfj.bmfj_132_17

Benha Med J

2018

DOI: 10.4103/bmfj.bmfj_132_17

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Noninvasive predictors of hepatic fibrosis in patients with chronic hepatitis C virus in comparison with liver biopsy

Ayman Menessy

Nancy Abdel Fattah Ahmed

Nagwa I Abdallah

et al.

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Potential role of noninvasive biomarkers during liver fibrosis

Kaur¹,

Goyal²,

Garg³

et al. 2021

WJH

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Various types of liver disease exist, such as hepatitis and alcoholic liver disease. These liver diseases can result in scarring of liver tissue, cirrhosis, and finally liver failure. During liver fibrosis, there is an excess and disorganized accumulation of extracellular matrix (ECM) components which cause the loss of normal liver cell functions. For patients with chronic liver disease, fibrosis prediction is an essential part of the assessment and management. To diagnose liver fibrosis, several invasive and noninvasive markers have been proposed. However, the adoption of invasive markers remains limited due to their inherent characteristics and poor patient acceptance rate. In contrast, noninvasive markers can expedite the clinical decision through informed judgment about disease stage and prognosis. These noninvasive markers are classified into two types: Imaging techniques and serum biomarkers. However, the diagnostic values of biomarkers associated with liver fibrosis have also been analyzed. For example, the serum levels of ECM proteins can react to either matrix accumulation or degradation. During virus-host interactions, several regulatory steps take place to control gene expression, such as the change in cellular microRNA expression profiles. MicroRNAs are a class of non-coding RNAs (18-20 long nucleotides) that function by post-transcriptional regulation of gene expression. Although various noninvasive markers have been suggested in recent years, certain limitations have restricted their clinical applications. Understanding the potential of non-invasive biomarkers as a therapeutic option to treat liver fibrosis is still in progress.

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Potential role of noninvasive biomarkers during liver fibrosis

Kaur¹,

Goyal²,

Garg³

et al. 2021

WJH

View full text Add to dashboard Cite

show abstract

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Noninvasive predictors of hepatic fibrosis in patients with chronic hepatitis C virus in comparison with liver biopsy

Cited by 1 publication

References 0 publications

Potential role of noninvasive biomarkers during liver fibrosis

Potential role of noninvasive biomarkers during liver fibrosis

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