Noninvasive Polarimetric-Based Glucose Monitoring: An <i>in Vivo</i> Study

Purvinis, Georgeanne; Cameron, Brent D.; Altrogge, Douglas M.

doi:10.1177/193229681100500227

Cited by 70 publications

(51 citation statements)

References 17 publications

(31 reference statements)

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“…As a result, polarimetric based techniques are nowadays being applied in multiple scenarios, as for instance, for cancer detection and stage identification [4][5][6][7][8], to enhance image contrast in skin diseases [9][10][11], for human eye examination [12,13], for diabetes diagnosis as well as therapy [14,15], etc.…”

Section: Introductionmentioning

confidence: 99%

Polarization gating based on Mueller matrices

et al. 2017

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Abstract. We present mathematical formulae generalizing polarization gating techniques. Polarization gating refers to a collection of imaging methods based on the combination of different controlled polarization channels. In particular, we show how using the measured Mueller matrix of a sample, a widespread number of polarization gating configurations can be evaluated just from analytical expressions based on the Mueller matrix coefficients. We also show the interest of controlling the helicity of the states of polarization used for polarization gating based metrology, as this parameter has an impact in the image contrast of samples. In addition, we highlight as well the interest of combining polarization gating techniques with tools of data analysis related to the Mueller matrix formalism, such as the well-known Mueller matrix decompositions. The method discussed in this work is illustrated with the results of polarimetric measurements done on artificial phantoms and real ex-vivo tissues.

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Section: Introductionmentioning

confidence: 99%

Polarization gating based on Mueller matrices

et al. 2017

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“…Other non-invasive approaches include polarimetry [20] Raman spectroscopy [21], photoacoustics [22], optical coherence tomography [23], and photothermal deflectometer enhanced by total internal reflection [24].…”

Section: Glucose Monitoring Methods: Invasive and Non-invasivementioning

confidence: 99%

Role of Peroxidase in Clinical Assays: A Short Review

Shivakumar¹,

Bg²,

Mr³

2017

J Clin Nutr Diet

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Development of sensitive enzymatic methods for hydrogen peroxide is key for the quantification of several bioconstituents such as glucose, triglycerides, creatinine, and uric acid and so on. Hydrogen peroxide released by the oxidase enzymes are quantified by peroxidase enzyme involving spectrophotometry, fluorimetry, chemiluminisence, potentiometric sensing, amperometric, coulometric and such others. Authors in this line, present a short review on the assay of peroxidase. The entire review is divided into three different sections; first the importance of peroxidase clinically, secondly peroxidase chemistry with hydrogen peroxide and finally its role in the assay of bioconstituents.Keywords: Peroxidase; Clinical importance; Oxidase enzymes; Glucose assay; Nano sensors Role of Peroxidase in ClinicalAssays: A Short Review Peroxidase: A Clinically Important EnzymePeroxidases are widely distributed in nature especially in animal and plant cells. Peroxidases comprise of three major categories; plant peroxidases, animal peroxidases and catalases. These enzymes utilize hydrogen peroxide to catalyze the oxidation of variety of organic and inorganic compounds.

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“…23 More recently, Purvinis et al used an openloop, single-wavelength polarimeter to measure the glucose concentration in the eye in vivo. 24 Therein, the motion artifacts were reduced and effectively eliminated by limiting animal motion, and the authors concluded that corneal birefringence compensation, along with closed-loop control, can provide more robust measurements.…”

Section: Introductionmentioning

confidence: 99%

Dual-wavelength polarimetric glucose sensing in the presence of birefringence and motion artifact using anterior chamber of the eye phantoms

2013

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Abstract. Noninvasive glucose monitoring is being investigated as a tool for effectively managing diabetes mellitus. Optical polarimetry has emerged as one such method, which can potentially be used to ascertain blood glucose levels by measuring the aqueous humor glucose levels in the anterior chamber of the eye. The key limitation for realizing this technique is the presence of sample noise due to corneal birefringence, which in the presence of motion artifact can confound the glucose signature in the aqueous humor of the eye. We present the development and characterization of a real-time, closed-loop, dual-wavelength polarimetric system for glucose monitoring using both a custom-built plastic eye phantom (in vitro) and isolated rabbit corneas (ex vivo) mounted in an artificial anterior chamber. The results show that the system can account for these noise sources and can monitor physiologic glucose levels accurately for a limited range of motion-induced birefringence. Using the dual-wavelength system in vitro and ex vivo, standard errors were 14.5 mg∕dL and 22.4 mg∕dL, respectively, in the presence of birefringence with motion. The results indicate that although dual-wavelength polarimetry has a limited range of compensation for motion-induced birefringence, when aligned correctly, it can minimize the effect of time-varying corneal birefringence for a range of motion larger than what has been reported in vivo.

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Noninvasive Polarimetric-Based Glucose Monitoring: An in Vivo Study

Cited by 70 publications

References 17 publications

Polarization gating based on Mueller matrices

Polarization gating based on Mueller matrices

Role of Peroxidase in Clinical Assays: A Short Review

Dual-wavelength polarimetric glucose sensing in the presence of birefringence and motion artifact using anterior chamber of the eye phantoms

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