Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10‐tetraazacyclodoecane‐α,α′,α″,α‴‐tetramethyl‐1,4,7,10‐tetraacetic acid (DOTMA<sup>4–</sup>)

Hekmatyar, S. K.; Hopewell, Paige; Pakin, S. Kubilay; Babsky, Andriy M.; Bansal, Navin

doi:10.1002/mrm.20345

Cited by 51 publications

(94 citation statements)

References 29 publications

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“…TmDOTMA À was synthesized from Tm 2 O 3 (Aldrich Chemical, St Louis, MO, USA) and Na 4 DOTMA (Macrocyclic, Dallas, TX, USA) as described earlier (24). TmDOTA À was obtained from Macrocyclic.…”

Section: Methodsmentioning

confidence: 99%

“…However, these chemical shifts are also strongly dependent on pH and Ca 2þ (16)(17)(18)(19). Thulium-based complexes of 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (DOTA À ) and 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetate (DOTMA À ) have also been explored (21,22,24). The general chemical structure of TmDOTA À and TmDOTMA À is shown in Fig.…”

Section: Introductionmentioning

confidence: 98%

“…The C T for the corresponding H 6 signal from TmDOTA À is 0.38 ppm/ C (21). 1 H chemical shifts of both TmDOTA À and TmDOTMA À are insensitive to the concentration of the paramagnetic complex, pH, Ca 2þ and the presence of plasma macromolecules and ions (21,22,24). The temperature sensitivity of Pr 3þ , Yb 3þ , Tm 3þ , Tb 3þ and Dy 3þ complexes of DOTMA 4À have also been examined to determine which complex is the most suitable for MR thermometry (24).…”

Section: Introductionmentioning

confidence: 99%

“…1 H chemical shifts of both TmDOTA À and TmDOTMA À are insensitive to the concentration of the paramagnetic complex, pH, Ca 2þ and the presence of plasma macromolecules and ions (21,22,24). The temperature sensitivity of Pr 3þ , Yb 3þ , Tm 3þ , Tb 3þ and Dy 3þ complexes of DOTMA 4À have also been examined to determine which complex is the most suitable for MR thermometry (24). Of the five lanthanide DOTMA 4À complexes examined, TmDOTMA À was found to possess the best combination of temperature sensitivity and linewidth.…”

Section: Introductionmentioning

confidence: 99%

“…The strong temperature dependence of the hyperfine chemical shifts of many paramagnetic complexes has been explored for MR thermometry (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24). The chemical shifts of the 1 H and 31 P signals from thulium-1, 4,7,10-tetraazacyclododecane-1,4,7,10-tetrakis(methylenephosphonate) (TmDOTP 5À ), which was introduced as an in vivo Na þ shift reagent (25,26), are two orders of magnitude more sensitive to temperature than the chemical shift of the water 1 H signal (16)(17)(18).…”

Section: Introductionmentioning

confidence: 99%

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Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA−)

et al. 2006

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Non-invasive thermometry using hyperfine-shifted MR signals from paramagnetic lanthanide complexes has attracted attention recently because the chemical shifts of these complexes are many times more sensitive to temperature than the water 1H signal. Among all the lanthanide complexes examined thus far, thulium tetramethyl-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate (TmDOTMA-) appears to be the most suitable for MR thermometry. In this paper, the feasibility of imaging the methyl 1H signal from TmDOTMA- using a frequency-selective radiofrequency excitation pulse and chemical shift-selective (CHESS) water suppression is demonstrated. A temperature imaging method using a phase-sensitive spin-echo imaging sequence was validated in phantom experiments. A comparison of regional temperature changes measured with fiber-optic probes and the temperatures calculated from the phase shift near each probe showed that the accuracy of imaging the temperature with TmDOTMA- is at least 0.1-0.2 degrees C. The feasibility of imaging temperature changes in an intact rat at 0.5-0.6 mmol/kg dose in only a few minutes is demonstrated. Similar to commonly used MRI contrast agents, the lanthanide complex does not cross the blood-brain barrier. TmDOTMA- may prove useful for temperature imaging in many biomedical applications but further studies relating to acceptable dose and signal-to-noise ratio are necessary before clinical applications.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA−)

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Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10‐tetraazacyclodoecane‐α,α′,α″,α‴‐tetramethyl‐1,4,7,10‐tetraacetic acid (DOTMA^4–)

Cited by 51 publications

References 29 publications

Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA−)

Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA−)

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Highly Sensitive MRI Chemical Exchange Saturation Transfer Agents Using Liposomes

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Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10‐tetraazacyclodoecane‐α,α′,α″,α‴‐tetramethyl‐1,4,7,10‐tetraacetic acid (DOTMA4–)

Cited by 51 publications

References 29 publications

Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA−)

Non-invasive temperature imaging with thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetramethyl-1,4,7,10-tetraacetic acid (TmDOTMA−)

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Highly Sensitive MRI Chemical Exchange Saturation Transfer Agents Using Liposomes

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Noninvasive MR thermometry using paramagnetic lanthanide complexes of 1,4,7,10‐tetraazacyclodoecane‐α,α′,α″,α‴‐tetramethyl‐1,4,7,10‐tetraacetic acid (DOTMA^4–)