Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease

Lee, Sang Kun; Park, Jung Eun; Lee, Kyungmi; Kang, Lami; Chu, Kon; Kim, Seung Up; Kim, Manho; Roh, Jae Kyu

doi:10.1016/j.jneumeth.2005.09.013

Cited by 47 publications

(44 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NPCs injected systemically into healthy animals were in fact never found in the CNS, while exclusively accumulating (and persisting only for a short period) in peripheral organs (Pluchino et al, 2003). Specific homing of transplanted NPCs has been shown, so far, in experimental brain stroke (Chu et al, 2003;Lindvall and Kokaia, 2011), SCI (Takeuchi et al, 2007), epilepsy (Chu et al, 2004;Hattiangady et al, 2008), HD (Lee et al, 2006), and glioblastoma (Aboody et al, 2000;Ahmed et al, 2011).…”

Section: Homing and Extravasationmentioning

confidence: 99%

How stem cells speak with host immune cells in inflammatory brain diseases

Pluchino

Cossetti

2013

Glia

110

109

View full text Add to dashboard Cite

Advances in stem cell biology have raised great expectations that diseases and injuries of the central nervous system (CNS) may be ameliorated by the development of non-hematopoietic stem cell medicines. Yet, the application of adult stem cells as CNS therapeutics is challenging and the interpretation of some of the outcomes ambiguous. In fact, the initial idea that stem cell transplants work only via structural cell replacement has been challenged by the observation of consistent cellular signaling between the graft and the host. Cellular signaling is the foundation of coordinated actions and flexible responses, and arises via networks of exchanging and interacting molecules that transmit patterns of information between cells. Sustained stem cell graft-to-host communication leads to remarkable trophic effects on endogenous brain cells and beneficial modulatory actions on innate and adaptive immune responses in vivo, ultimately promoting the healing of the injured CNS. Among a number of adult stem cell types, mesenchymal stem cells (MSCs) and neural stem/precursor cells (NPCs) are being extensively investigated for their ability to signal to the immune system upon transplantation in experimental CNS diseases. Here, we focus on the main cellular signaling pathways that grafted MSCs and NPCs use to establish a therapeutically relevant cross talk with host immune cells, while examining the role of inflammation in regulating some of the bidirectionality of these communications. We propose that the identification of the players involved in stem cell signaling might contribute to the development of innovative, high clinical impact therapeutics for inflammatory CNS diseases.

show abstract

Section: Homing and Extravasationmentioning

confidence: 99%

How stem cells speak with host immune cells in inflammatory brain diseases

Pluchino

Cossetti

2013

Glia

110

109

View full text Add to dashboard Cite

show abstract

“…Moreover, the upregulation of migration was shown under the influence of brain-derived neurotrophic factor (BDNF) [23]. The migration phenomena are now harnessed in the stem cell research field, especially in the MRI context, and there are accumulating data that demonstrate how exogenous stem cells of various origins migrate in the CNS [7,8,24], and specifically toward QA-induced lesion [25].…”

Section: Introductionmentioning

confidence: 99%

Migration of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Toward a Quinolinic Acid Lesion as Viewed by Magnetic Resonance Imaging

et al. 2008

View full text Add to dashboard Cite

show abstract

“…Mesenchymal Stem Cells: Chronic inflammation has an important rule for the pathogenesis of AD [94], transplantation of Mesenchymal stem cells (MSCs) elevates the level of many anti-inflammatory Cytokines including IL-10 & PGE2 thus improve cognitive functions in transgenic AD mice [95]. Cord-blood derived MSCs showed to stimulate production of neprilysin in microglial tissue [96]. Even human cord blood shown to modulate signaling of CD40 thus reduces AD pathology [97].…”

Section: Neural Progenitor Cells (Gabaergic Interneuron Precursor Celmentioning

confidence: 99%

Stem Cells for Neuro-regeneration: State of the Art

Wagih¹,

Elhawary²,

Ellessy³

et al. 2015

BIO

View full text Add to dashboard Cite

Neuroregeneration (NR) is a long-sought medical dream which has intrigued vast research in the past decades. A traditional physiologic dogma that central nervous system does not regenerate has been strongly challenged in the recent years since the advent of the stem cell era. Stem cell research in the regenerative field passes through three main stages. The first stage is the in-vitro experiments which studies the exact molecular and cellular mechanisms underlying stem cell-mediated NR. The second stage is the application of these data in experimental animal settings to provide "proof of concept" of stem cell therapy in animal models. The final step is the translation of these data in pilot clinical trials. In this review, we will try to gather the different data of stem cell-mediated NR from various experimental and clinical researches.

show abstract

Noninvasive method of immortalized neural stem-like cell transplantation in an experimental model of Huntington's disease

Cited by 47 publications

References 23 publications

How stem cells speak with host immune cells in inflammatory brain diseases

How stem cells speak with host immune cells in inflammatory brain diseases

Migration of Neurotrophic Factors-Secreting Mesenchymal Stem Cells Toward a Quinolinic Acid Lesion as Viewed by Magnetic Resonance Imaging

Stem Cells for Neuro-regeneration: State of the Art

Contact Info

Product

Resources

About