Noninvasive method for measurement of cerebral blood flow using O-15 water PET/MRI with ASL correlation

Okazawa, Hidehiko; Higashino, Yoshifumi; Tsujikawa, Tetsuya; Arishima, Hidetaka; Mori, Tetsuya; Kiyono, Yasushi; Kimura, Hirohiko; Kikuta, Ken-ichiro

doi:10.1016/j.ejrad.2018.05.033

Cited by 28 publications

(63 citation statements)

References 24 publications

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“…Performance tests showed the intrinsic resolution of PET images to be 4.2-4.3 mm full width at half maximum (FWHM) in the transaxial direction. The PET/MRI scanner was calibrated with a dose-calibrator (CRC-12, Capintec Inc., NJ, USA) beforehand using a pool phantom and 18 F-solution, according to the scanner manufacturer's guidelines [9].…”

Section: Pet/mri Scannermentioning

confidence: 99%

“…Dynamic PET images were reconstructed from the PET data using the 3D ordered-subset expectation maximization (OSEM) method and point spread function (PSF) modeling algorithm in 39 frames of 12 × 5 s, 6 × 10 s, 3 × 20 s, 4 × 30 s, 5 × 60 s, 4 × 5 m, and 4 × 10 m. Time-activity curves were obtained from the dynamic PET data using the image-derived input function (IDIF) method described previously [9,12]. The initial 21 frames for 3 min after tracer injection were used for calculation of CBF.…”

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

“…Details of the IDIF estimation from PET/MRI data are described elsewhere [9]. In brief, the average image of the initial phase (10-40 s) of dynamic PET data was used to extract voxels only inside the ICA, where the 30 most intensely radioactive voxels were selected as the volume of interest (VOI) mask at the region of the cavernous part of the ICA.…”

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

“…Individual 3D TOF-MRA images were used to confirm the location of the arterial VOI mask precisely on the ICA. Time-activity curves for IDIF were obtained by applying the ICA VOI masks on the dynamic PET data [9,12]. Arterial input functions for the initial 3 min were estimated from IDIF total blood radioactivity.…”

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

“…CBF images (mL/min/100 g) were calculated based on a one-tissue compartment model using the threeweighted integral calculation method [14,15]. In this method, an image of K 1 , the tissue influx rate constant of PET tracer, was calculated first, and the image was then converted to a CBF image using an extraction fraction (E) of 0.65 which was estimated from previous reports where K 1 of [ 11 C]PiB was calculated [16,17], and CBF values in healthy controls on PET/MRI in our previous study [9], using an equation of K 1 = E × CBF. The dispersion in the peripheral arteries was automatically corrected in the program with a fixed constant of 4 s. No delay correction of tracer arrival time between C p and the major cerebral arteries was needed because the input function was obtained from the same dynamic PET data at the skull base [9].…”

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

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Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease

et al. 2020

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Background: Multimodal PET/MRI image data simultaneously obtained from patients with early-stage of Alzheimer's disease (eAD) were assessed in order to observe pathophysiologic and functional changes, as well as alterations of morphology and connectivity in the brain. Fifty-eight patients with mild cognitive impairment and early dementia (29 males, 69 ± 12 years) underwent [ 11 C]Pittsburgh compound-B (PiB) PET/MRI with 70-min PET and MRI scans. Sixteen age-matched healthy controls (CTL) (9 males, 68 ± 11 years) were also studied with the same scanning protocol. Cerebral blood flow (CBF) was calculated from the early phase PET images using the image-derived input function method. A standardized uptake value ratio (SUVr) was calculated from 50 to 70 min PET data with a reference region of the cerebellar cortex. MR images such as 3D-T1WI, resting-state functional MRI (RS-fMRI), diffusion tensor image (DTI), and perfusion MRI acquired during the dynamic PET scan were also analyzed to evaluate various brain functions on MRI. Results: Twenty-seven of the 58 patients were determined as eAD based on the results of PiB-PET and clinical findings, and a total of 43 subjects' data including CTL were analyzed in this study. PiB SUVr values in all cortical regions of eAD were significantly greater than those of CTL. The PiB accumulation intensity was negatively correlated with cognitive scores. The regional PET-CBF values of eAD were significantly lower in the bilateral parietal lobes and right temporal lobe compared with CTL, but not in MRI perfusion; however, SPM showed regional differences on both PET-and MRI-CBF. SPM analysis of RS-fMRI delineated regional differences between the groups in the anterior cingulate cortex and the left precuneus. VBM analysis showed atrophic changes in the AD group in a part of the bilateral hippocampus; however, analysis of fractional anisotropy calculated from DTI data did not show differences between the two groups. Conclusion: Multimodal analysis conducted with various image data from PiB-PET/MRI scans showed differences in regional CBF, cortical volume, and neuronal networks in different regions, indicating that pathophysiologic and functional changes in the AD brain can be observed from various aspects of neurophysiologic parameters. Application of multimodal brain images using PET/MRI would be ideal for investigating pathophysiologic changes in patients with dementia and other neurodegenerative diseases.

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Section: Pet/mri Scannermentioning

confidence: 99%

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

Section: Pet Reconstruction and Image Calculation Of Cbf And Suvmentioning

confidence: 99%

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Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease

et al. 2020

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Simultaneous phase‐contrast MRI and PET for noninvasive quantification of cerebral blood flow and reactivity in healthy subjects and patients with cerebrovascular disease

Ishii

Thamm

Guo

et al. 2019

Magnetic Resonance Imaging

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Background: H 2 15 O-positron emission tomography (PET) is considered the reference standard for absolute cerebral blood flow (CBF). However, this technique requires an arterial input function measured through continuous sampling of arterial blood, which is invasive and has limitations with tracer delay and dispersion. Purpose: To demonstrate a new noninvasive method to quantify absolute CBF with a PET/MRI hybrid scanner. This blood-free approach, called PC-PET, takes the spatial CBF distribution from a static H 2 15 O-PET scan, and scales it to the whole-brain average CBF value measured by simultaneous phase-contrast MRI. Study Type: Observational. Subjects: Twelve healthy controls (HC) and 13 patients with Moyamoya disease (MM) as a model of chronic ischemic disease. Field Strength/Sequences: 3T/2D cardiac-gated phase-contrast MRI and H 2 15 O-PET. Assessment: PC-PET CBF values from whole brain (WB), gray matter (GM), and white matter (WM) in HCs were compared with literature values since 2000. CBF and cerebrovascular reactivity (CVR), which is defined as the percent CBF change between baseline and post-acetazolamide (vasodilator) scans, were measured by PC-PET in MM patients and HCs within cortical regions corresponding to major vascular territories. Statistical Tests: Linear, mixed effects models were created to compare CBF and CVR, respectively, between patients and controls, and between different degrees of stenosis. Results: The mean CBF values in WB, GM, and WM in HC were 42 AE 7 ml/100 g/min, 50 AE 7 ml/100 g/min, and 23 AE 3 ml/100 g/min, respectively, which agree well with literature values. Compared with normal regions (57 AE 23%), patients showed significantly decreased CVR in areas with mild/moderate stenosis (47 AE 17%, P = 0.011) and in severe/occluded areas (40 AE 16%, P = 0.016). Data Conclusion: PC-PET identifies differences in cerebrovascular reactivity between healthy controls and cerebrovascular patients. PC-PET is suitable for CBF measurement when arterial blood sampling is not accessible, and warrants comparison to fully quantitative H 2 15 O-PET in future studies. Level of Evidence: 3 Technical Efficacy Stage: 2

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Hyperpolarized ¹²⁹Xe imaging of the brain: Achievements and future challenges

Shepelytskyi

Grynko

Rao

et al. 2022

Magnetic Resonance in Med

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Hyperpolarized (HP) xenon‐129 (129Xe) brain MRI is a promising imaging modality currently under extensive development. HP 129Xe is nontoxic, capable of dissolving in pulmonary blood, and is extremely sensitive to the local environment. After dissolution in the pulmonary blood, HP 129Xe travels with the blood flow to the brain and can be used for functional imaging such as perfusion imaging, hemodynamic response detection, and blood–brain barrier permeability assessment. HP 129Xe MRI imaging of the brain has been performed in animals, healthy human subjects, and in patients with Alzheimer's disease and stroke. In this review, the overall progress in the field of HP 129Xe brain imaging is discussed, along with various imaging approaches and pulse sequences used to optimize HP 129Xe brain MRI. In addition, current challenges and limitations of HP 129Xe brain imaging are discussed, as well as possible methods for their mitigation. Finally, potential pathways for further development are also discussed. HP 129Xe MRI of the brain has the potential to become a valuable novel perfusion imaging technique and has the potential to be used in the clinical setting in the future.

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Noninvasive method for measurement of cerebral blood flow using O-15 water PET/MRI with ASL correlation

Cited by 28 publications

References 24 publications

Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease

Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease

Simultaneous phase‐contrast MRI and PET for noninvasive quantification of cerebral blood flow and reactivity in healthy subjects and patients with cerebrovascular disease

Hyperpolarized ¹²⁹Xe imaging of the brain: Achievements and future challenges

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Noninvasive method for measurement of cerebral blood flow using O-15 water PET/MRI with ASL correlation

Cited by 28 publications

References 24 publications

Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease

Multimodal analysis using [11C]PiB-PET/MRI for functional evaluation of patients with Alzheimer’s disease

Simultaneous phase‐contrast MRI and PET for noninvasive quantification of cerebral blood flow and reactivity in healthy subjects and patients with cerebrovascular disease

Hyperpolarized 129Xe imaging of the brain: Achievements and future challenges

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Hyperpolarized ¹²⁹Xe imaging of the brain: Achievements and future challenges