Noninvasive Measurement of Steady and Pulsating Velocity Profiles and Shear Rates in Arteries Using Echo PIV: In Vitro Validation Studies

Kim, Hyoung-Bum; Hertzberg, Jean; Lanning, Craig; Shandas, Robin

doi:10.1114/b:abme.0000036643.45452.6d

Cited by 64 publications

(49 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we have shown experimentally 25,26 and other investigators have shown clinically 27 by echocardiographic particle imaging velocimetry 28 that transmitral flow can produce an intraventricular rotational body of fluid referred to as a vortex ring. [29][30][31] A vortex ring has been shown to support more efficient fluid transport compared with a straight jet alone 32,33 ; thus, formation of a vortex alongside a diastolic filling jet suggests efficient transmitral blood transport.…”

mentioning

confidence: 62%

Patients With Alzheimer Disease Have Altered Transmitral Flow

Bělohlávek

Jiamsripong

Calleja

et al. 2009

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

Objective. There is considerable epidemiologic evidence that Alzheimer disease (AD) is linked to cardiovascular risk factors and associated with an increased risk of symptomatic left ventricular (LV) dysfunction. Formation of a vortex alongside a diastolic jet signifies an efficient blood transport mechanism. The vortex formation time (VFT) is an index of optimal conditions for vortex formation. We hypothesized that AD and its associated cardiovascular risk factors impair diastolic transmitral flow efficiency and, therefore, shift the VFT value out of its optimal range. Methods. Echocardiographic studies were performed on 45 participants in total: 22 patients with AD diagnosed according to the American Psychiatric Association's criteria and 23 age-matched individuals as a control group with cognitive function within normal limits. Results. The echocardiographic ratio of the early to atrial phases of the LV filling velocities was significantly lower in the AD group (mean ± SD, 0.67 ± 14) when compared with the control individuals (0.79 ± 0.14; P = .003). The interventricular septum diastolic thickness, left ventricular posterior wall diastolic thickness, and right ventricular end-diastolic diameter were significantly higher in the AD group (P ≤ 0.04). The mitral annular diameters in the control and AD groups were nearly identical (P = .725). The time-velocity integral of the E wave had a lower value in the AD group than in the control group (P = .05), whereas the VFT was significantly lower in the AD group (P = .018). Conclusions. Our study suggests that patients with AD have impaired transmitral flow efficiency of diastolic filling, as measured by the VFT, compared with agematched control individuals. Key words: Alzheimer disease; blood flow velocity; diastolic function; vortex formation.

show abstract

mentioning

confidence: 62%

Patients With Alzheimer Disease Have Altered Transmitral Flow

Bělohlávek

Jiamsripong

Calleja

et al. 2009

Journal of Ultrasound in Medicine

View full text Add to dashboard Cite

show abstract

“…To induce a large amount of scattering, high concentrations of scattering particles are applied. However, due to the requirement of very high particle concentrations (Kim et al 2004a), the application of USV for in vivo applications is limited. Additionally, the presence of velocity gradients seriously affects the USV performance (Adrian 1991).…”

Section: Introductionmentioning

confidence: 99%

Perpendicular ultrasound velocity measurement by 2D cross correlation of RF data. Part A: validation in a straight tube

et al. 2010

View full text Add to dashboard Cite

An ultrasound velocity assessment technique was validated, which allows the estimation of velocity components perpendicular to the ultrasound beam, using a commercially available ultrasound scanner equipped with a linear array probe. This enables the simultaneous measurement of axial blood velocity and vessel wall position, rendering a viable and accurate flow assessment. The validation was performed by comparing axial velocity profiles as measured in an experimental setup to analytical and computational fluid dynamics calculations. Physiologically relevant pulsating flows were considered, employing a blood analog fluid, which mimics both the acoustic and rheological properties of blood. In the core region (|r|/a \ 0.9), an accuracy of 3 cm s -1 was reached. For an accurate estimation of flow, no averaging in time was required, making a beat to beat analysis of pulsating flows possible.

show abstract

“…Hence, the method produces instantaneous, two-dimensional velocity vector fields. UIV has been used to study flow in straight [23,24] and curved tubes [25], vessel phantoms [26] and vortex phantoms [27], and for preliminary in vivo investigations in healthy arteries [26,28 -30] and the heart [28,31].…”

Section: Introductionmentioning

confidence: 99%

Ultrasound imaging velocimetry with interleaved images for improved pulsatile arterial flow measurements: a new correction method, experimental and in vivo validation

Fraser

Poelma

Zhou

et al. 2017

J. R. Soc. Interface.

View full text Add to dashboard Cite

Blood velocity measurements are important in physiological science and clinical diagnosis. Doppler ultrasound is the most commonly used method but can only measure one velocity component. Ultrasound imaging velocimetry (UIV) is a promising technique capable of measuring two velocity components; however, there is a limit on the maximum velocity that can be measured with conventional hardware which results from the way images are acquired by sweeping the ultrasound beam across the field of view. Interleaved UIV is an extension of UIV in which two image frames are acquired concurrently, allowing the effective interframe separation time to be reduced and therefore increasing the maximum velocity that can be measured. The sweeping of the ultrasound beam across the image results in a systematic error which must be corrected: in this work, we derived and implemented a new velocity correction method which accounts for acceleration of the scatterers. We then, for the first time, assessed the performance of interleaved UIV for measuring pulsatile arterial velocities by measuring flows in phantoms and in vivo and comparing the results with spectral Doppler ultrasound and transit-time flow probe data. The velocity and flow rate in the phantom agreed within 5-10% of peak velocity, and 2-9% of peak flow, respectively, and in vivo the velocity difference was 9% of peak velocity. The maximum velocity measured was 1.8 m s 21 , the highest velocity reported with UIV. This will allow flows in diseased arteries to be investigated and so has the potential to increase diagnostic accuracy and enable new vascular research.

show abstract

Noninvasive Measurement of Steady and Pulsating Velocity Profiles and Shear Rates in Arteries Using Echo PIV: In Vitro Validation Studies

Cited by 64 publications

References 34 publications

Patients With Alzheimer Disease Have Altered Transmitral Flow

Patients With Alzheimer Disease Have Altered Transmitral Flow

Perpendicular ultrasound velocity measurement by 2D cross correlation of RF data. Part A: validation in a straight tube

Ultrasound imaging velocimetry with interleaved images for improved pulsatile arterial flow measurements: a new correction method, experimental and in vivo validation

Contact Info

Product

Resources

About